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Cathy Silver Key
Assistant Professor
ckey@nccu.edu
Department of Biology
North Carolina Central University
Tazswana’s Story: How Alternative mRNA Splicing Leads to Genetic Disease

In this directed case study, students read about a little girl with beta-thalassemia, a life-threatening disease. Through a series of increasingly complex activities, they learn how alternative pre-mRNA processing (splicing) has caused her disease and how gene therapy that targets the process may provide a cure. The case was developed for a junior-level genetics course, but could be modified for use in a cell, molecular genetics, or molecular biology course.