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A Case of Genetic Bad Luck?
Anne M. Casper
In this case, developed for an introductory genetics class, students meet a woman whose family has a history of colon cancer. Students create a pedigree based on information from the case and discuss what it means to be genetically predisposed to cancer. Using bioinformatics tools from the NCBI database, students identify and examine the mutation in the woman’s APC gene that results in genetic predisposition to colon cancer. Finally, they investigate the biological function of the APC protein to understand why this mutation contributes to the development of cancer and determine whether APC is a proto-oncogene, tumor suppressor gene, or genome stability gene.
|Keywords:||Colon cancer; pedigree; genetic testing; APC gene; NCBI database; BLAST; ORF Finder; oncogene; tumor suppressor|
|Educational Level:||High school, Undergraduate lower division|
|Subject Headings:||Genetics / Heredity Molecular Biology Bioinformatics|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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