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Living With Her Genes
Early Onset Familial Alzheimer's Disease
Lynne H. Gildensoph
Alice M. Stanford
Deborah D. Wygal
When a 30-year-old genetic counselor learns that her 38-year-old sister has developed early onset familial Alzheimer’s disease (EOFAD), a dominantly inherited disorder that led to their father's death at age 42, she struggles with whether to undergo genetic testing and whether to have children. This interrupted case study examines the impact of genetic testing on people and their families when there is no treatment or cure for a disease. It covers principles of Mendelian inheritance as well as genetic and reproductive technologies ,such as gene tests, pre-implantation genetic diagnosis, and in vitro fertilization. It can be used in introductory biology courses for both majors and non-majors or adapted for more advanced courses in genetics and molecular biology.
|Keywords:||Alzheimer's; neurodegenerative disease; early onset; DNA; allele; APP gene; autosomal dominant; meiosis; genetic counselor; pre-implantation genetic diagnosis; PGD; in vitro fertilization; IVF; Human Genome Project; bioethics|
|Topical Area:||Ethics, Social issues|
|Educational Level:||Undergraduate lower division, Undergraduate upper division, Graduate|
|Subject Headings:||Biology (General) Molecular Biology Genetics / Heredity|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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