- Teaching Notes
- Answer Key
Karen A. Pinco
This case study was developed to complement the study of the immune system and to emphasize the crosstalk that occurs at the cellular level between B and T cells for proper immune system function. In reading the story of a young couple trying to understand the cause of their infant boy’s constant bacterial infections, students review the different classes of antibodies, their specific functions, and how they arise through isotype switching. In addition, students apply their knowledge of basic genetics as they examine how X-linked disorders are passed along and the role of genetic counselors in medicine.
|Keywords:||X-linked agammaglobulinemia with hyper-IgM syndrome; CD40 ligand; immune system; IgM; IgG; T cells; bone marrow transplant; isotype switching; immunoglobulin; pedigree; genetic counselor|
|Educational Level:||High school, Undergraduate lower division|
|Subject Headings:||Genetics / Heredity Physiology|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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