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The Case of Baby Joe
Chronic Infections in an Infant
Kristen L.W. Walton
This interrupted case study follows the declining health of an infant who suffers from recurrent infections and finally is diagnosed with severe combined immunodeficiency (SCID). The case was developed for use in an undergraduate upper-level immunology course to supplement discussion of B and T cell development and the generation of antibody diversity. It could also be modified for use in a genetics class, with emphasis on the molecular aspects of RAG-mediated recombination and inheritance patterns of the disease, or a pathophysiology class, with emphasis on the physiology underlying the symptoms.
|Keywords:||Immunology; immune system; antibody diversity; B cell; T cell; T cell receptor; TCR; recombination activating gene enzyme; RAG; immunodeficiency; somatic recombination recessive allele; severe combined immunodeficiency; SCID; infection|
|Educational Level:||Undergraduate lower division, Undergraduate upper division|
|Subject Headings:||Biology (General) Medicine (General) Genetics / Heredity|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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