New search
download case
  • Overview
  • Teaching Notes
  • Answer Key
  • Comments/Replies

Baby Doe v. The Prenatal Clinic

When Cell Division Goes Awry



Author:

Norris Armstrong
Biology Department
University of Georgia
narmstro@uga.edu

Abstract:

This "clicker case" presents a fictionalized story about a couple ("John" and "Jane") whose new baby is born with Down syndrome; the parents are suing the prenatal clinic where Jane received her care, blaming the clinic for the baby’s condition. Designed for an introductory biology course, the case has students assume the role of an expert witness hired by a law firm to give evidence in the case. To help determine the cause of "Baby Doe’s" condition and whether anyone can be held responsible for it, students need to help the jury understand the process of cell division. In particular, they must explain the behavior of the chromosomes during cell division and how errors in this process can result in conditions such as Down syndrome. The case is presented in class using PowerPoint slides (~1.8 MB) that are punctuated by multiple-choice questions the students respond to using hand-held personal response systems (clickers).  It could be adapted for use without these technologies.

Objectives:
  • Understand that DNA is stored on multiple chromosomes and that, during cell division, DNA is tightly compacted/packaged.
  • Explain that cells/organisms may have multiple, slightly different versions of the same chromosome referred to as homologous chromosomes. Cells that contain one copy of each chromosome are said to be haploid. Cells that contain two copies are diploid.
  • Describe what sister chromatids are and how they arise. DNA replication results in two identical copies of the same chromosome called sister chromatids. Sister chromatids remain physically connected together until near the end of cell division.
  • Describe the major steps of mitosis/meiosis and what processes occur in each step.
  • Draw a diagram and explain how the chromosomes behave during cell division and how this behavior differs between mitosis and meiosis.
  • Explain how cells can have too many or too few copies of a chromosome due to errors during division and chromosome segregation.
  • Understand that Down syndrome usually results from an extra copy of chromosome 21. (Partial copies can, though less frequently, result in the same syndrome.)
  • Explain how other syndromes associated with errors in chromosome segregation such as Turner (XO), Kleinfelter (XXY), and XYY syndromes as well as aneuploidy in many cancers may have occurred.
  • Describe how to use karyotypes to examine chromosomes in developing embryos.
Keywords: Mitosis; meiosis; chromosome; cell division; trisomy; Downs; Down syndrome; Kleinfelter; Turner syndrome; aneuploidy
Topical Area: N/A
Educational Level: Undergraduate lower division
Formats: PDF
Type/Method: Clicker, Interrupted, Role-Play
Language: English
Subject Headings: Biology (General)   Cell Biology   Medicine (General)  
Date Posted: 01/15/10
Date Modified: N/A
Copyright: Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.

Teaching Notes


Case teaching notes are password-protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, begin the process by registering here.

Teaching notes are intended to help teachers select and adopt a case. They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources.

  Download Teaching Notes

Answer Key


Answer keys for the cases in our collection are password-protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, begin the process by registering here.


  Get Answer Key



Name:
Email:
Department:
Institution:
City State:
Comments:
security code
Enter Security Code: