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The Case of the Druid Dracula



Author:

Peggy Brickman
Department of Plant Biology
University of Georgia
brickman@uga.edu

Abstract:

This case is based on a lurid crime featured on the BBC program Crimewatch in December 2001 that was solved thanks to forensic DNA analysis. Students learn how the structure of DNA and the mechanism used by cells to duplicate DNA were critical to the forensic analysis. They then determine the statistical validity of the forensic data in the same way a prosecutor would prepare the case for a courtroom. Written for an introductory biology course of 300+ students, the teaching notes for the case describe how students work in permanent small groups in a lecture hall setting to collaboratively solve the case in class.

Objectives:
  • Understand the similarities and differences in the DNA of humans and how those differences can be exploited for forensic identification.
  • Understand the structure of DNA and how hydrogen bonds between the nucleotide bases dictate the complementary nature of the double helix. Students will be able to predict the nucleotide sequence of one strand of DNA in a double helix if given its complementary strand.
  • Describe the technique of polymerase chain reaction (PCR) and relate it to the normal cellular process of DNA replication. Students will be able to predict the sequence of PCR primers that would amplify just one short stretch of DNA out of an entire genome.
  • Understand how short tandem repeats (STRs) within human chromosomes can be used to generate fingerprints and how to interpret these fingerprints to match the DNA to a specific person.
  • Use statistical prevalence of STRs to determine the probability that someone else at random in the population could have DNA that matched a sample found at a crime scene.
Keywords: DNA fingerprinting; polymerase chain reaction; PCR; DNA replication; short tandem repeats; STR; amelogenin; AMELX; restriction fragment length polymorphism; RFLP; murder case; criminal investigation; forensic investigation; Wales
Topical Area: N/A
Educational Level: Undergraduate lower division
Formats: PDF
Type/Method: Interrupted
Language: English
Subject Headings: Biology (General)   Molecular Biology   Forensic Science  
Date Posted: 06/27/06
Date Modified: N/A
Copyright: Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.

Teaching Notes


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Answer Key


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