- Teaching Notes
- Answer Key
The Complexity of a Human Genetic Disease
This case study follows a young couple that is consulting with a genetic counselor about their plans to have a child. Because of their family history with cystic fibrosis, they are concerned about their chances of having a child with this genetic disease. The case study reviews the basics of Mendelian and molecular genetics in humans, briefly examines the possibilities and limitations of genetic testing, and introduces students to online databases, including OMIM, a catalog of human genetic traits. The case also requires students to practice the scientific method, including hypothesis development, experimental design, and the analysis of primary research articles. Although developed for use as an introductory unit to an upper-level genetics course, the case could be adapted for an introductory biology course, perhaps as a closing exercise to a unit on molecular genetics.
|Keywords:||Genetics; cystic fibrosis; CF; genetic disease; genetic testing; pedigree analysis; Punnett square; mutation; gene structure; gene regulation; human inheritance; experimental design|
|Topical Area:||Scientific method|
|Educational Level:||Undergraduate lower division, Undergraduate upper division|
|Type/Method:||Interrupted, Journal Article|
|Subject Headings:||Genetics / Heredity Molecular Biology Biology (General) Medicine (General)|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
Case teaching notes are password-protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, begin the process by registering here.
Teaching notes are intended to help teachers select and adopt a case. They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources.
Download Teaching Notes
Answer keys for the cases in our collection are password-protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, begin the process by registering here.
Get Answer Key