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FOXP2 and Speech
A Gene Expression Case
FOXP2 was first identified as a human language gene when a mutated version of the gene was found to cause speech problems in the KE family in London. In 2009, a research team transferred the cloned FOXP2 gene into mice and demonstrated that the FOXP2 transgenic mice made different sounds. This "clicker case" uses personal response systems (aka clickers) and a PowerPoint presentation with multiple-choice questions to explore the cutting-edge science behind this discovery. Figures adapted from peer-reviewed research articles are also used to teach about gene expression and the steps for creating a transgenic mouse. The case was developed for an introductory biology course for non-science majors and science majors but could be expanded for an upper-level molecular biology or a biotechnology course.
|Keywords:||FOXP2; gene expression; transcription; translation; mutation; recombinant DNA; transgenic organism; mouse; human speech; language; human genetics; genetic engineering|
|Topical Area:||Scientific method|
|Educational Level:||Undergraduate lower division, Undergraduate upper division|
|Type/Method:||Clicker, Interrupted, Journal Article|
|Subject Headings:||Genetics / Heredity Biology (General) Molecular Biology Biotechnology Communication Science|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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