- Teaching Notes
- Answer Key
- Supplemental Materials
Resistance Is Futile, Or is It? The Clicker Version
Steven L. Telleen
This clicker case is an adaptation of a case by Annie Prud'homme-Généreux that was originally published by the National Center for Case Study Teaching in Science titled "Resistance Is Futile ... or Is It? The Immunity System and HIV Infection." It has been reformatted to use clickers and a PowerPoint presentation, and is reduced in scope to fit a 90-minute class. The case uses the results of the landmark paper by Paxton and his colleagues (Paxton et. al., 1996) that offered the first breakthrough in understanding why some people are protected against HIV infection. During the presentation, students make hypotheses, predict the outcome of experiments, and compare their predictions with real data. This adaptation was developed for use in an undergraduate, lower-division human physiology class when covering the immune system. Instructors interested in using it are advised to read the teaching notes for the original case for a full background.
|Keywords:||HIV; human immunodeficiency virus; retrovirus; reverse transcriptase; T cell; immune system; immunity; AIDS; acquired immunodeficiency syndrome; infectious disease; experimental design; data interpretation|
|Topical Area:||Scientific method|
|Educational Level:||High school, Undergraduate lower division|
|Type/Method:||Clicker, Discussion, Interrupted, Journal Article|
|Subject Headings:||Biology (General) Molecular Biology Cell Biology Physiology Microbiology Medicine (General) Public Health|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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The supplemental material below may be used with this case study:Click and Learn: Cells of the Immune System
An 11-slide presentation with accompanying worksheet that describes the non-specific defense system called the innate and adaptive immune system. Produced by HHMI BioInteractive.
VideosThe following video(s) are recommended for use in association with this case study.
HIV Life Cycle
A short video clip explaining how HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery. Running time: 4:52 min. Produced by HHMI BioInteractive.