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Hemophilia

The 'Royal Disease'



Co Authors:

Yelena Aronova-Tiuntseva
Department of Biological Sciences
University at Buffalo

Clyde Freeman Herreid
Department of Biological Sciences
University at Buffalo
herreid@buffalo.edu

Abstract:

This case deals with the genetics of the hemophilic condition that afflicted the royal families of Europe.  Students trace the pedigrees of the descendants of Queen Victoria and the passage of the recessive X-linked trait from ancestor to ancestor. The case is suitable for courses in general biology at either the high school or college level.

Objectives:
  • Provide a real example of pedigree analysis of a sex-linked trait.
  • Provide students an opportunity to calculate probabilities of the transmission of a genetic trait.
Keywords: Hemophilia; haemophilia; hemophiliac; recessive disorder; genetic disease; sex-linked trait; blood; hemoglobin; Queen Victoria; Tsarevich Alexei Nikolaevich; Romanovs
Topical Area: N/A
Educational Level: High school, Undergraduate lower division
Formats: PDF
Type/Method: Directed, Discussion, Interrupted
Language: English
Subject Headings: Genetics / Heredity   Biology (General)   Medicine (General)  
Date Posted: 05/1/99
Date Modified: 03/05/12
Copyright: Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.

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