New search
download case
  • Overview
  • Teaching Notes
  • Answer Key
  • Comments/Replies

One Headache After Another: Biochemistry Edition



Co Authors:

Ann T.S. Taylor
Department of Chemistry
Wabash College
taylora@wabash.edu

William H. Cliff
Department of Biology
Niagara University
bcliff@niagara.edu

Abstract:

Topamax®, developed to treat epilepsy, is also used as a preventative for migraine. In this case study, students read about a woman experiencing a side-effect of Topamax and from there move to a review of acid-base balance in the human body. The case study questions force the students to think about basic concepts related to buffers, pH, and equilibria, and challenge them to make specific connections. The case has two versions: one for chemists/biochemists and a second for physiologists. This is the biochemistry version.  Both versions cover acid-base balance to a similar extent, with the physiology version (titled "One Headache After Another: Physiology Edition") covering more of the factors involved with metabolic acidosis and exercise physiology. Both versions are geared to upper-level undergraduates.

Objectives:
  • Recall and use buffer system definitions, Henderson Hasselbalch equation, and titration curves, in reference to carbonic acid and bicarbonate.
  • Use Hess's law to adjust the pKa of carbonic acid.
Keywords: pH; buffer; acid/base; LeChatlier principle; metabolic acidosis; physiological regulation of pH; carbonic anhydrase; Henderson Hasselbalch equation; Hess's Law; titration curves; topiramate; Topamax; respiratory system; renal system; kidneys
Topical Area: N/A
Educational Level: Undergraduate upper division
Formats: PDF
Type/Method: Directed, Interrupted
Language: English
Subject Headings: Biochemistry   Chemistry (General)   Biology (General)   Medicine (General)  
Date Posted: 12/28/2009
Date Modified: N/A
Copyright: Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.

Teaching Notes


Case teaching notes are password-protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, begin the process by registering here.

Teaching notes are intended to help teachers select and adopt a case. They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources.

  Download Teaching Notes

Answer Key


Answer keys for the cases in our collection are password-protected and access to them is limited to paid subscribed instructors. To become a paid subscriber, begin the process by registering here.


  Get Answer Key



Name:
Email:
Department:
Institution:
City State:
Comments:
security code
Enter Security Code: