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The Mona Lisa Molecule: Mysteries of DNA Unraveled
This case study details the historical discovery of the structure of DNA. Images of this key molecule are as iconic as those of the Mona Lisa, and identifying its structure has proven to be as intriguing a mystery for scientists as the reason behind Mona Lisa's smile has been for art historians. The case is woven together by a series of fictional diary entries that detail the history of the discovery of DNA's structure, the major players involved, their ethical dilemmas, and the role of women in science. The case is designed for a high school course or introductory undergraduate genetics/ biochemistry courses. It can also be used as an interdisciplinary case study bridging genetics, bioethics, art, and the status of women in science. Designed as an interrupted case, it may be used in its entirety or in parts that pertain to a particular topic or discipline. No prior knowledge of genetics is required.
|Keywords:||DNA; deoxyribonucleic acid; x-ray crystallography; model building; double helix; Rosalind Franklin; Francis Crick; James Watson; Cavendish; Hershey-Chase; Chargraff’s Laws; photo 51|
|Topical Area:||Ethics, History of science, Science and the media, Women in science|
|Educational Level:||High school, Undergraduate lower division|
|Type/Method:||Analysis (Issues), Dilemma/Decision, Discussion, Interrupted, Journal Article|
|Subject Headings:||Biology (General) Genetics / Heredity Biochemistry Molecular Biology|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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VideosThe following video(s) are recommended for use in association with this case study.
The Double Helix
Short film that tells the story of the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. Running time: 16:53 min. Produced by HHMI BioInteractive. ec)
The Chemical Structure of DNA
Short animation showing the detailed structure of DNA. Running time: 2:44 mins. Produced by HHMI BioInteractive.
Short animation that discusses Erwin Chargaff’s 1950 publication stating that in the DNA of any given species, the ratio of adenine to thymine is equal, as is the ratio of cytosine to guanine. This became known as Chargaff's ratio, and it was an important clue for solving the structure of DNA. Running time: 0;49 min. Produced by HHMI BioInteractive.