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The Ebola Wars: General Edition
Tracie M. Addy
Linda M. Iadarola
This case study introduces students to viruses and is suitable for a general biology course. Terry is a college student who travels to a West African clinic for the summer as a volunteer. While abroad, Terry comes into contact with a patient infected with the Ebola virus and later displays the signs and symptoms of an Ebola virus infection. Over the course of the case study Terry learns about the general features of viruses, viral life cycles, in addition to the unique features of the Ebola virus and treatment options. The case is presented in an interrupted fashion. Students are expected to have prior knowledge of protein, lipid and nucleic acid structure and function, the parts of the cells (e.g., the properties of the cell membrane and the role of ribosomes) and the central dogma (e.g., the processes of transcription and translation). An advanced version of the case, intended for upper level undergraduate and graduate students, is also available on this site.
|Keywords:||Viruses; Ebola virus; Ebola therapy; viral structure; infection; viral life cycle; disease; capsid; glycoproteins; immunotherapy; ZMapp|
|Educational Level:||High school, Undergraduate lower division|
|Subject Headings:||Biology (General) Medicine (General) Microbiology|
|Copyright:||Copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.|
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VideosThe following video(s) are recommended for use in association with this case study.
Viral Life Cycle
This short animation illustrates how delivery of a single virus to a cell allows the virus to infect the cell, replicate, and give rise to many progeny viruses. These viruses can then infect neighboring cells. Running time: 1:08 min. Produced by HHMI BioInteractive.
Click-and-Learn: Virus Explorer
Explore the similarities and differences of a variety of viruses including the Ebola virus by sorting them based on structure, genomic make-up, host range, transmission mechanism, and vaccine availability. Running time: Self-paced. Produced by HHMI BioInteractive.