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A Case of Medication Error
This case study begins with a real news article about a six-month-old baby who died from an overdose of medication administered by hospital staff. The infant was diagnosed with pneumonia and given an intravenous dose of the antibiotic azithromycin, the...

A Case of Respiratory Distress
This clinical case study was developed to engage students by making connections between core concepts in chemistry and physiological processes in the body. The case pertains to medication-induced methemoglobinemia, its etiology, diagnosis, and treatmen...

A Diet to Die For
This clicker case is designed to lead students to a conceptual understanding of oxidative phosphorylation (and, by analogy, photosynthesis). Students begin with a pre-class handout that presents background information on DNP, a weight-loss drug that wa...

A Metabolic Storm
This "clicker" case presents the true story of a 20-year-old athlete who developed a life threatening reaction to anesthesia during a simple elective surgical procedure. His response was unexpected, but not unusual for individuals who possess an inheri...

Agony and Ecstasy
This interrupted case study explores the scientific, legal, and societal complexities of repurposing an illicit substance, 3,4-methylenedioxymethamphetamine (MDMA), also known as "Ecstasy" or "Molly," into a clinically accepted medicine for treating po...

Amanda's Absence
When chronic pain forces a top student to withdraw from college, biology instructor Dr. Sharpe learns that medications (in this case, Vioxx) may be removed from the market for many reasons, including safety concerns. As the case unfolds, students learn...

An Infectious Cure
This four-part interrupted case on phage therapy was developed for a freshmen non-majors course in molecular biology. The case begins with a story inspired by real events where Europeans imposed a treatment for cholera on the unwilling population of an...

Antibiotic Resistance in a Russian Prison
In this case study, students will have the opportunity to model the spread of tuberculosis and development of antibiotic resistance in a hypothetical prison environment. After reading a brief handout and viewing a short video, students play a simulatio...

Anxiety Doesn’t Work
This case study tells the story of Mo, an individual with social anxiety disorder who seeks mental health treatment. The purpose of this case is not to have students diagnose the central figure, but rather to help students gain insight into on...

Are You Blue? What Can You Do?
This case study introduces students to treatment alternatives for depression using a jigsaw method in which groups of students are divided up so that each member of the “home group” becomes the “resident expert” in one of five p...

Born for Recovery: The Effects of Maternal Methadone Use on Neonates
This interrupted case study presents the story of "Jane Paul," a 27-year-old pregnant woman excited by the prospect of bringing a new life into the world. Jane had been using heroin for the past seven years, but when she learns she is pregnant, she goe...

Cats Have Nine Lives, But Only One Liver
In this case, a college student gives her cat Tylenol not knowing its potential harmful effects. The cat survives, but the incident motivates her to research the reaction mechanism underlying the liver toxicity of acetaminophen. The case outlines po...

Danielle's Difficulty
The incidence of Clostridium difficile infection (CDI), including severe infection, has increased in both institutional settings and the general community. This case study presents the story of an elderly woman who spent time in a hospital and...

Discovering Long-Term Care Pharmacy Practice
This three-part progressive disclosure case is designed to introduce pharmacy students to the pharmacist’s role in long-term care (LTC) facility consulting pharmacy practice and acquaint them with the essential, basic resources for conducting a d...

Does a One-Size Drug Dose Fit All?
The purpose of this case study is to make students aware that some patients may require individualized drug dosing regimens based on a variety of patient variables. The central classroom activity consists of small group work in which students analyze a...

Drug Wars: An Epic Tale of Asthma and Bacterial Pneumonia
This case study is based on real events that the author experienced with her 10-year-old daughter. Although the names have been changed, all of the events (symptoms, diagnoses, treatments, types of healthcare professionals) are recorded exactly as they...

East Meets West
Ying is sick and is progressively getting worse. His parents' clashing views on Eastern and Western medicine prevent them from agreeing on a course of treatment. As the case unfolds, students follow the progression of their son's illness. After a physi...

Ethnomedicine in Latino Communities of Madison
This PowerPoint-delivered case study guides the reader, a hypothetical student intern with the City of Madison (Wisconsin) Public Health Department, as he/she assists a physician who was awarded a grant to investigate the use of herbal medicines by Lat...

Football Fanaticism
A fight in a college town bar between the football player of one team and a drunken fan of a rival team results in a serious spinal cord injury. Students working in groups read the case and research the questions associated with it, which they then dis...

From Cow Juice to a Billion Dollar Drug, With Some Breakthroughs in Between
Before the discovery of insulin in 1921, being diagnosed with Type 1 diabetes was a death sentence. Despite the successful management of diabetes with purified animal insulin, potentially severe side effects were abundant, and alternative ways to produ...

How a Cancer Trial Ended in Betrayal
In this case study, students learn about the complexities and issues associated with clinical trials. After reading a newspaper story about a fraudulently conducted clinical trial involving a treatment for skin cancer, students simulate their own small...

Hyper-IgM Syndrome
Hyper-IgM syndrome is an X-linked genetic disorder more commonly affecting males than females. It is caused by the lack of heavy chain class-switching from IgM to other isotypes. Patients with hyper-IgM syndrome are susceptible to a variety of infectio...

Is That Pill You're Taking Safe?
This dilemma cased is based on the actual development, FDA approval, and market withdrawal of dexfenfluramine, a drug used in the late 1990s in combination with phentermine for weight loss. The case is set up as a mock trial, with students taking the r...

Mini Cases in Psychoactive Drugs and Their Effects on the Brain
Designed for an upper-level psychology class titled Brain & Behavior, this series of mini-cases can be used in any undergraduate course that covers the major classes of commonly abused legal and illicit psychoactive drugs from a biological...

Morgan: A Case of Diabetes
This case teaches about the causes and effects of Type 2 diabetes by working through the various options available to a young Native American woman suffering from the disease. The case can be used in a variety of settings, including nutrition classroom...

Mother's Milk Cures Cancer?
This case study on the immune system, cell cycle regulation, and cancer biology explores the role that serendipity plays in new discoveries in science, how scientific research is funded, and the personal and professional implications of unexpectedly fi...

Muscleman
This case is designed to help students develop a deeper understanding of negative feedback regulation. Basic principles of negative feedback systems are illustrated by focusing on the effects of anabolic steroids on the hypothalamic-pituitary-testicula...

New Ways to Breathe
This case study follows a young cystic fibrosis (CF) patient named Lucas. Through Lucas's story and interactions between his parents and pediatrician, students learn about the scientific background and basis of CF. By reviewing email correspondence bet...

One Tablet a Day May Keep Cancer Away
This dilemma/decision case study is intended to demonstrate how knowledge of signal transduction pathways can be applied to the pharmaceutical industry and within a medical setting. The case scenario revolves around a physician scientist's analysis of ...

Pharmacogenetics: How Genetic Information Is Used to Treat Disease
In this clicker case, two teenagers are diagnosed with Acute Lymphoblastic Leukemia (ALL), a cancer of the bone marrow where there is an abnormal overproduction of lymphocyte precursors. The girls' reactions to treatment are very different, however, du...

Pharmacogenetics: Using Genetics to Treat Disease
This case study investigates the applications of genetics to medicine by exploring one of the first examples of a pharmacogenetic test to enter mainstream clinical practice. Pharmacogenetics examines how genetic variations in an individual correlate wi...

Sarah's Sickness
This story is based on the true account of a student who suffered years of misdiagnoses of her illness while she was in a professional school. As the case evolves, students follow the course of Sarah's illness. Part I of the case details the signs of h...

Sometimes Less is Better
“Ed Cramer” is a 47-year-old mechanical engineer who is being treated for venous thromboembolism. He was 45 when he first developed a blood clot in the lower part of his left leg and had to be hospitalized for five days. A year later, he de...

The Case of a Tropical Disease and its Treatment
This case study highlights the epidemiological and socioeconomic factors associated with a disease which plagues thousands of people in Central and South America.  The case follows the story of Adrian, a banana plantation worker in southwestern Co...

The Case of Ruth James
In this case, designed for beginning pharmacy students, an elderly woman apparently “in excellent health” suddenly becomes ill and health care practitioners must determine the cause. The case is written in a four-part progressive disclosure...

The Case of the Crying Baby
The parents of a six-week-old baby girl know there is something seriously wrong with their child, but it takes a number of frustrating visits to the pediatrician before they finally get a correct diagnosis. Once they do, the parents must decide whether...

The Challenge of Epilepsy
This case study was originally developed for undergraduate science students as part of an extracurricular competition, but it could also be delivered as a directed case. Accordingly two versions of the activity are included. Each version requires stude...

The Haemophilus Vaccine
This case study focuses on a young mother whose child attends a day care center where there has been an outbreak of bacterial meningitis. The case explores the need for health care workers to provide relevant medical information and advice to patients,...

The Medicinal Use of Marijuana
Whether marijuana should be legalized for medicinal purposes has been contested for decades. The claims, counter-claims, issues, and judgments in this high profile controversy make it an excellent candidate for “intimate debate.” While simi...

When a Gene Turned Off Is a Matter of Life or Death
When Jordan is diagnosed with brain cancer (glioblastoma multiforme), his college plans are unexpectedly put on hold. This scenario is presented in order to teach students about gene regulation, as the efficacy of the drug Jordan receives for post-surg...

When Drug Sales and Science Collide
When "Jeff," a fictionalized drug representative, is placed on the Vioxx® account in 2001, he finds himself pulled between sales and science as he struggles to reconcile three original documents: a Merck marketing pamphlet, a graph from a scientifi...