Si el Norte Fuera el Sur
In this case study, students are given the task of developing a recovery plan to protect a recently discovered population of Central American squir...

Case Study
The Dating Game
In this role-playing case study, students attempt to determine the identity of a variety of human fossils based on characteristics described during...

Case Study
Trouble in Paradise
In this case study, students apply principles of evolution they have learned in class to create their own story explaining the evolutionary history...

Case Study
The Galapagos
Using problem-based learning and role-playing, students analyze the geological origins of the Galapagos Islands, their colonization, species forma...

Case Study
The Evolution of Creationism
This PBL case on Intelligent Design was written for freshman biology majors at a Christian liberal arts college. Students read about the claims and...

Case Study
We Are Not Alone
This interrupted case study for the flipped classroom introduces the human microbiome from the perspective of one of its occupants, Heidi Helicobac...

Case Study
The Missing Link
The setting for this case study is a paleontological dig in East Africa, where “Sam,” an American undergraduate student, has unearthed ...

Case Study
The Molecular Origin of Life: Replication or Metabolism-First? Advanced Version
This case explores both the evidence and inconsistencies in the two major hypotheses for the origins of life on Earth: Replication-First or Metabol...

Case Study
The Molecular Origin of Life: Replication or Metabolism-First? Introductory Version
This case explores both the evidence and inconsistencies in the two major hypotheses for the origins of life on Earth: Replication-First or Metabol...

Case Study
Equal Time for Intelligent Design?
Whether Intelligent Design should be taught in a science classroom is a serious problem. This case study tackles the issue head-on by using intimat...

Case Study
Abracadabra
This case introduces students to HIV, its life cycle, treatment, and problems associated with treatment options. The case, which incorporates criti...

Case Study
My Brother's Keeper
In this interrupted case study, students work in teams to interpret behavioral data with respect to evolutionary biology.  Specifically, the c...

Case Study
No Bats in the Belfry
This interrupted case study investigates the geographic origin of white-nose syndrome (WNS) in little brown bats (Myotis lucifugus). WNS i...

Case Study
The Case of the Sexually Arrested Orangutans
This case examines the hormonal control of the development and maturation to adulthood and the role of stress hormones in that developmental proces...

Case Study
The Story of Dinosaur Evolution
In this case study, students write their own “evolution stories” based on information taken from a review article by Paul Sereno on the...

Case Study
Why Sex is Good
This interrupted case is based on a 2005 article in Nature written by three scientists from the Imperial College London that deals with th...

Case Study
Poor Devils
Cancer is usually thought to be a disease that affects individuals. But could cancer evolve to become infectious? This case follows the research on...

Case Study
A Rainbow of Sepia
This flipped case study examines the selective pressures that have affected the evolution of diverse human skin pigmentations. To prepare for the c...

Case Study
Hidden in Plain Sight
As nonliving entities, viruses face specific challenges when replicating in a host.  Avoiding the host immune system is something that every v...

Case Study
An Antipodal Mystery
The discovery of the platypus had the scientific world in an uproar and kept it tantalized for decades. Here was the strangest animal ever seen. Ho...

Case Study
Chimpanzee Droppings Lead Scientists to Evolutionary Discovery
This interrupted case study focuses on the research of Dr. Beatrice Hahn, who investigates DNA sequences in chimpanzee droppings in order to explor...

Case Study
Exaggerated Traits and Breeding Success in Widowbirds
Sexual selection has led to the evolution of interesting traits and behaviors in many animal species. In widowbirds, males undergo a dramatic chang...

Case Study
I'm Looking Over a White-Striped Clover
This case is an exploration of the process of natural selection using white clover (Trifolium repens) as an example. In general, two forms...

Case Study
Man's Best Friend?
In this case, students learn how archaeology operates as an historical science by collecting and analyzing material evidence to make claims about t...

Case Study
Mom Always Liked You Best
This interrupted case study is based on a journal article on the parenting behavior of American coots. Working through the case, students develop h...

Case Study
PKU Carriers
In this interrupted case study, students read about a college student with phenylketonuria (PKU).  Students learn how diet affects a person wi...

Case Study
Something’s Fishy in Paxton Lake
In this interrupted case study, students explore the mechanisms of speciation while working in groups to design a series of experiments to determin...

Case Study
Testing for Grazer Adaptation to Toxic Algae
The intent of this interrupted case study is to present a clear example of both the scientific method and evolutionary adaptation in a model system...

Case Study
The Case of Desiree's Baby
This case is based on Kate Chopin’s short story “Desiree’s Baby,” a tragic tale of race and gender in antebellum Louisiana ...

Case Study
The Itsy-Bitsy Spider: An Analysis of Spider Locomotion
The evolution of physiological characteristics can be strongly influenced by physics. Animals whose physiology allows them to better escape predato...

Case Study
The Waiting Game
In this interrupted case study, students examine the cooperative courtship behavior of long-tailed manakins. Males of the long-tailed form leks, ar...

Case Study
The Evolving Genetics of Disease Resistance
This interrupted case study for the flipped classroom applies evolutionary genetics research to human health. Students learn about a naturally occu...

Case Study
Do You See What Eye See?
A common misconception is that Darwin suggested that something as complex as the eye could not have evolved through natural selection. While the mi...

Case Study
It’s a Crocodile! No, a Fish! No, a Dolphin!
It is not uncommon to hear creationists argue that evolution is not science because no one saw it happen, or for students to wonder how we can know...

Case Study
Revolt of the Fungus People
This interrupted case study for the flipped classroom examines the interaction of plants and their mycorrhizal partners. The latter is one of the m...

Case Study
Breakfast of Champions
This case study was developed for an upper-level undergraduate evolution course in order to provide an example of natural selection in hominids and...

Case Study
Evolution in Action
This case study is based on Dr. Richard Lenski’s ongoing studies of evolution in E. coli. Students are introduced to prokaryotic bio...

Case Study
Joel E. Greengiant Learns About Peas
This case study follows purveyors of peas, Joel E. and Jolene Greengiant, as they learn about the origin, biochemistry, genetics and eventual artif...

Case Study
The Evolution of Color Vision in Monkeys
This case study examines the evolution color vision in Old World and New World monkeys from multiple biological perspectives. This integrative appr...

Case Study
Do Corridors Have Value in Conservation?
This case study discusses conservation corridors as a means to reduce the problems of population size and isolation in a fragmented habitat. In an ...

Case Study
A Strange Fish Indeed
Through a series of fictionalized diary entries, this case recounts the 1939 discovery by Marjorie Courtenay-Latimer (and identification by J.L.B...

Case Study
Coping with Infection
This interrupted case study introduces two distinct, but not mutually exclusive, strategies for defending against parasites: resistance and toleran...

Case Study
The Evolution of Human Skin Color
While the concept of evolution by natural selection is very simple, it is often misunderstood by students. This is partly due to preconceptions the...

Case Study
Speciation and the Threespine Stickleback
This case study teaches students about allopatric speciation through an investigation of the benthic and limnetic sticklebacks of Paxton Lake, whic...

Case Study
Bad Blood
The ethics of human experimentation are explored in this case about the infamous syphilis studies performed at the Tuskegee Institute from the 1930...

Case Study
Of Mammoths and Men
The discovery of a mammoth frozen in the Siberian tundra is the backdrop for this case study, which explores theories for the extinction of the gre...

Case Study
I Scream for Ice Cream
Lactose intolerance, caused by a lack of persistent lactase enzyme expression, is a trait commonly observed in adult humans, with varying geographi...

Case Study
Just a Spider Bite?
This case relates the story of two fictional college students, Kristen and Brent, who discover that they are infected with Staphylococcus aureu...

Case Study
Life Tables, Darwin’s Finches, and the Dynamics of Small Island Populations
This case study uses Darwin’s finches to teach students about life tables. Life tables are tables of statistics that relate to life expectanc...

Case Study
The Spark of Life
In biology classes, students are typically taught that spontaneous generation does not take place. And yet, at the origin of life, life had to aris...

Case Study
En Garde! Animal Structures and What They Mean
In most animals, the drive to breed and produce offspring is strong. However, most males live their whole lives without having the chance to breed....

Case Study
One Whale or Two or … ?
This case study focuses on the intersection of defining a scientific species and defining a legal species. The compelling story of Lolita, an orca ...

Case Study
Do Grasshoppers Sweat?
There are many adaptive and evolutionary behaviors displayed in an organism's use of water. Although students generally have a superficial understa...

Case Study
Shooting the Poop
This group-based case study is based on research by Dr. Martha Weiss using silver-spotted skipper caterpillars (Epargyreus clarus (Lepidop...

Case Study
The Riddle of the Red Queen
This case study introduces students to the "Red Queen Hypothesis." The hypothesis states that when two species compete for a limited resource or ex...

Case Study
Little Mito
This case presents a fanciful story about the origin of the eukaryotic cell, a major milestone in the evolution of life. The characters of the stor...

Case Study
The Death of Baby Pierre
This directed case study on a genetic disorder was developed for an exam on genetics for a general biology course.  The case is based on an ar...

Case Study
Watch Your Step
This case makes use of the concept of the "ecological footprint," developed by Wackernagel and colleagues to quantify the amount of land area requi...

Case Study
Seven Skeletons and a Mystery
This problem-based learning case uses Archaeopteryx, the most famous fossil in the world, to show the vital role that fossils play in unde...

Case Study
The Modern Caveman’s Dilemma
During the Paleolithic era, human life expectancy was only 33 years—roughly half of what it is today. We owe our more extended lives in part ...

Case Study
Rabbit Calicivirus Disease - Magic Bullet or Pandora's Box?
The characters in this dilemma case, representing the scientific community and government, must make a decision about whether or not to release a v...

Case Study
MDR Tuberculosis
In this case study on multi-drug resistant (MDR) tuberculosis, students consider ways in which to preserve health as a human right without subjecti...

Case Study
And Now What, Ms. Ranger?
Intelligent Design continues to be a hot political and educational topic in some parts of the country. This discussion case study uses the dramatic...

Case Study
Wrestling with Weight Loss
In this interrupted case study, a young wrestler considers purchasing 2,4-dinitrophenol (DNP) online as a means to drop weight quickly. However, a ...

Case Study
Cancer Cure or Conservation
This case is based on the controversy that surrounded harvesting of the Pacific yew from 1989 to 1997 to develop paclitaxel (Taxol), a revolutionar...

Case Study
As the Worm Turns
At what point in evolutionary development does a group of individuals become two distinct species? This case addresses that fundamental question by...

Case Study
Butterfly Hunt
This case study uses an interactive activity to illustrate density dependence in ecology classes. We developed a "hunt" using paper butterflies wit...

Case Study
Torn at the Genes
The setting for this case is the family dinner table, where a heated discussion about genetically altered foods is taking place. Marsha Cumberland&...

Case Study
Ecology of Individuals: Using Game Theory to Understand Animal Behavior
This case study is based on the game theory developed by John Maynard Smith where two behavioral strategies ("Hawks" and "Doves") compete over a co...

Case Study
Prairie Garden of Troubles
This "clicker case" was developed for a general biology course for non-majors. It focuses on prairie habitat ecology and restoration. Jim, a young ...

Case Study
When Wilma Met Fred
This "clicker case" follows a professor and his students in a study abroad course in Tanzania who are searching for human fossils in an effort to b...

Case Study
A Deadly Passion
This "clicker case" teaches students about the distinction between proximate and ultimate causes of behavior using the fascinating courtship and ma...

Case Study
A Tale of Three Lice
This “clicker case” explores the questions of when hominins lost their body hair and began wearing clothing by examining the surprising...

Case Study
Breeding Belyaev's Pets
This clicker case addresses several important concepts related to evolution. First, it explores artificial selection and selective breeding. Charle...

Case Study
Cross-Dressing Salmon
This "clicker case" about female mimicry in spawning salmon was developed for an introductory-level, non-majors biology course to help address one ...

Case Study
Dark Skin, Blond Hair
This interrupted case is based on a genome wide association study (GWAS) that identified the genetic variation causing some inhabitants of the Solo...

Case Study
Darwin's Finches and Natural Selection
In this "clicker case," students learn about natural selection through the research of Peter and Rosemary Grant and colleagues on the finches of th...

Case Study
Not Necessarily on Purpose
In this “clicker case,” students learn about evolution, speciation, and natural selection as well as interpret phylogenies as they appl...

Case Study
Reproductive Isolation in Columbines
This clicker case uses plant-pollinator interactions in columbines as a biological scenario to teach students about evolution, reproductive isolati...

Case Study
The Boy in the Temple
This interrupted case study examines molecular genetic evidence reported in scientific literature to determine the fate of Louis-Charles, son of Lo...

Case Study
The Coelacanth: An Odd Fish
This "clicker case" is a redesign of a case, also in our collection, by Robert H. Grant titled "A Strange Fish Indeed: The 'Discovery' of a Living ...

Case Study
What is a Species?
This "clicker case" is modified from Martin Kelly's case study "As the Worm Turns: Speciation and the Apple Maggot Fly," also in our collection. Cl...

Case Study
How Many More Thymes? A Case of Phytochemical Defense
This clicker case addresses several concepts related to the evolutionary ecology of herbivore defenses. A survey of several different studies that ...

Case Study
Las alas del Diablo
Why are chilies so hot? This case study begins with a story about an undergraduate student who is inspired to learn about capsaicin production in c...

Case Study
Giant Pandas, Hormones, and the Evolution of a Lazy Bear
This clicker case study looks at the role of hormone cascades in homeostatic control of metabolism in a charismatic organism, the Giant Panda. ...

Case Study
Hidden in Plain Sight
This case study tells the story of John and Mary, two first-year college students learning about biodiversity while on a trip to Costa Rica where t...

Case Study
Selection on a Case by Case Basis
This "clicker case" gives students an opportunity to apply their understanding of three different types of selection (directional, stabilizing, and...

Case Study
Animals Can Run Away, but Plants Must Stay
In this PowerPoint-driven case study, students consider the many challenges faced by plants and discuss which of these might induce a morphological...

Case Study
Bioluminescence and 16th-century Caravaggism
This case study looks at the probable connection between bioluminescence and Caravaggio's painting style in the 16th century in order to explore th...

Case Study
Selection and the Blond Beach Mouse
This "clicker" case study explores ultimate and proximate explanations for cryptic coloration in animals through the work of Dr. Hopi Hoekstra of H...

Case Study
Blood Suckers! A Case Study on Evolution and Speciation
This directed case study in PowerPoint format focuses on the London Underground Mosquito, Culex molestus, and its potential relationship t...

Case Study
A Whale of a Tale?
For years whale evolution was characterized by speculation and limited evidence. Evolution critics even focused on whales as a means to criticize e...

Case Study
Got Blood?
The Aedes aegypti mosquito is the major vector for transmission of numerous viral diseases, including yellow fever, dengue, and now, Zika....

Case Study
SNPs and Snails and Puppy Dog Tails, and That's What People Are Made Of
In this case on genome privacy, students work together to research one of six assigned lobbying groups’ views in this area and then present t...

Case Study
Threats to Biodiversity
In this case study, students learn about introduced species and how they pose a threat to biodiversity by analyzing the impact of introduced specie...

Case Study
Evolution and Plasticity in Guppies
This case study focuses on the relationship between evolution and plasticity using a hands-on, inquiry-based approach. Students view examples from ...

Case Study
Evolution by Natural Selection in Oldfield Mice
The theory of evolution by natural selection is simple, elegant, and profound. Yet, a large number of undergraduate students including biology majo...

Case Study
Patient Zero
Emerging diseases and potential pandemics make the news nearly every year. Students (and everyone else) may wonder where new infectious diseases co...

Case Study
Super Bug
Sam, a pre-med college student, routinely gets dialysis and develops a urinary tract infection. The infection is from a bacterium that the news med...

Case Study
Retro Goes Modern
This case study considers the evolution of HIV from SIV, as well as the evolution of HIV within humans by mutation rate. It also discusses the immu...

Case Study
Mutualism
This case explores two-species interactions, especially mutualism, and presents students with a problem, namely, the inconsistent treatment of the ...

Case Study
No Matter If You’re Black or White
Human populations have adapted to varying intensities of sunlight with varying tones of skin coloration. The balanced interplay between melanin con...

Case Study
A Decision to Branch Out
In this flipped case study, students use the scientific method to investigate how changes in a few genes have shaped the evolution of maize plant a...

Case Study
Host-Pathogen Interactions
This case study introduces students to the complex field of immunology and the wide variety of host-pathogen interactions that drive evolutionary c...

Case Study
A Simple Plan
This case study introduces students to Dr. E.L. Trudeau, who performed a seminal early experiment validating the germ theory of infection. Part I i...

Case Study
The Path of a Pathogen
Scientists and healthcare professionals initially exhibited little concern over the Zika virus even after evidence of human infection was first ide...

Case Study
MRSA in the NICU
DNA sequencing and analysis (bioinformatics) is an increasingly important tool for understanding biological data, including medical data. In this c...

Case Study
Murder by HIV? Grades 5-8 Edition
This case study gives students an opportunity to draw a conclusion about an actual crime that was prosecuted in Louisiana. A physician was accused ...

Case Study
Murder by HIV? Grades 9-12 Edition
This case study gives students an opportunity to draw a conclusion about an actual crime that was prosecuted in Louisiana. A physician was accused ...

Case Study
Murder by HIV? Undergraduate Edition
This case study gives students an opportunity to draw a conclusion about an actual crime that was prosecuted in Louisiana. A physician was accused ...

Case Study
Which Came First, the Mutation or the Antibiotic?
This case study presents the story of Phil, an undergraduate majoring in biology, whose Russian cousin Dimitri has contracted tuberculosis (TB) fro...

Case Study
Should Dinosaurs Be Cloned from Ancient DNA?
Michael Crichton's Jurassic Park, as a novel and then a blockbuster movie, reawakened the public's fascination with dinosaurs. Although di...

Case Study