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Pandemic Pandemonium

Why Can’t We Just Treat COVID-19?


Author(s)

Melissa Kosinski-Collins
Department of Biology
Brandeis University
kosinski@brandeis.edu
Lindsay Mehrmanesh
Department of Biology
Brandeis University
lmehrmanesh@brandeis.edu
Jessie Cuomo
Department of Biology
Brandeis University
jcuomo@brandeis.edu
Kene N. Piasta
Department of Biology
Brandeis University
kpiasta@brandeis.edu

Abstract

This directed case study was designed for introductory level or mid-level biology students to serve as a capstone project incorporating aspects of nucleic acid, lipid and protein structure and function, central dogma, and virus life cycles. The storyline follows two young girls and their family during the 2019–2020 coronavirus outbreak in the United States. Students explore the differences between SARS-CoV-2, which causes COVID-19, and other viruses like herpes, influenza and HIV.  They examine the structure of SARS-CoV-2 and how it binds to and enters a cell. They consider the genome of SARS-CoV-2, which consists of RNA-based nucleic acids, and its mechanism of translation. One of the girls in the story tests positive for COVID-19 and her parents consider multiple antiviral treatments approved for influenza, HIV and herpes. Students then research the mechanism of action of these antivirals, suggest why they will not be successful in treating COVID-19, and predict possible antiviral targets specific for SARS-CoV2. The case concludes with a writing assignment in which students use what they have learned in the case and address ethical questions involved with sharing patient information.


Objectives

  • Describe the structural characteristics of the SARS-CoV-2 virus.
  • Draw the life cycle of SARS-CoV-2 and contrast it to the life cycle of a different DNA virus, herpes simplex.
  • Compare the cellular and biochemical characteristics of SARS-CoV-2, herpes simplex virus-1, HIV, and influenza B.
  • Compare and contrast antibiotic and antiviral treatments. Analyze how different antiviral therapies work. Compare the efficacy of both when treating COVID-19.
  • Understand the importance and ethics of sharing personal information about disease.

Keywords

COVID-19; SARS-CoV-2; coronavirus; antivirals; virus; viral life cycle; central dogma;

Topical Areas

Ethics

Educational Level

High school, Undergraduate lower division, Undergraduate upper division

Format

PDF

Type / Methods

Directed

Language

English

Subject Headings

Biology (General)  |   Cell Biology  |  


Date Posted

3/31/2020

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