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Good to the Bone

Biological Implications of a Potential Anti-Aging Drug


Author(s)

Nalini V. Broadbelt
School of Arts and Sciences
MCPHS University
nalini.broadbelt@mcphs.edu
Michelle A. Young
School of Arts and Sciences
MCPHS University
michelle.young@mcphs.edu

Abstract

This case study is designed to introduce students to how the bone’s architecture influences movement and the roles cells play in bone growth and repair. It tells the story of “Maria,” an active 68-year-old woman who works on a farm. Over the last five years, Maria has experienced pain in her wrist and knee joints and has used a nonsteroidal anti-inflammatory drug (ibuprofen) to deal with the pain. In the course of cleaning her home in preparation for a visit from her grandchildren, she falls and breaks a bone in three places. After reading the short case scenario and relevant journal articles, students are asked a series of questions designed to teach facts about bone anatomy, physiology and pathology underlying the patient’s condition. This case study was designed for use in both freshman-level and advanced-level courses in human anatomy and physiology. It could also be used for a biology pathology course. Before starting the case, students should have a basic understanding of the anatomy and physiology of bones.


Objectives

  • Compare and contrast the different types of joints and how their structure and shape dictates movement.
  • Describe the location and function of bone structures.
  • Explain the processes of bone construction and destruction involved in the homeostasis of bone.
  • Distinguish the roles of osteochondral progenitor cells, osteoblasts, osteoclasts, and osteocytes.
  • Understand the process by which bone is repaired following an injury.
  • Describe the process by which bone is repaired following an injury.
  • Describe how the drug metformin can influence bone growth and repair and could potentially be used to treat osteoporosis and arthritis.
  • Read and analyze graphical data.

Keywords

Joint; bone; bone repair; fracture; metformin; osteoporosis; arthritis; graph; osteoblasts; osteoclasts; calcium; phosphorus; data analysis; remodeling; osteoporosis

Topical Areas

N/A

Educational Level

Undergraduate lower division, Undergraduate upper division

Format

PDF

Type / Methods

Analysis (Issues), Discussion, Interrupted

Language

English

Subject Headings

Biochemistry  |   Biology (General)  |   Cell Biology  |   Medicinal Chemistry  |   Medicine (General)  |   Organic Chemistry  |  


Date Posted

10/23/2020

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