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Hemophilia

The 'Royal Disease'


Author(s)

Yelena Aronova-Tiuntseva
Department of Biological Sciences
University at Buffalo
Clyde Freeman Herreid
Department of Biological Sciences
University at Buffalo
herreid@buffalo.edu

Abstract

This case deals with the genetics of the hemophilic condition that afflicted the royal families of Europe.  Students trace the pedigrees of the descendants of Queen Victoria and the passage of the recessive X-linked trait from ancestor to ancestor. The case is suitable for courses in general biology at either the high school or college level.


Objectives

  • Provide a real example of pedigree analysis of a sex-linked trait.
  • Provide students an opportunity to calculate probabilities of the transmission of a genetic trait.

Keywords

Hemophilia; haemophilia; hemophiliac; recessive disorder; genetic disease; sex-linked trait; blood; hemoglobin; Queen Victoria; Tsarevich Alexei Nikolaevich; Romanovs

Topical Areas

N/A

Educational Level

High school, Undergraduate lower division

Format

PDF

Type / Methods

Directed, Discussion, Interrupted

Language

English

Subject Headings

Genetics / Heredity  |   Biology (General)  |   Medicine (General)  |  


Date Posted

05/1/99

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