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From Cow Juice to a Billion Dollar Drug, With Some Breakthroughs in Between


Author(s)

Justin F. Shaffer
Department of Chemical and Biological Engineering
Colorado School of Mines
jshaffer@mines.edu

Abstract

Before the discovery of insulin in 1921, being diagnosed with Type 1 diabetes was a death sentence. Despite the successful management of diabetes with purified animal insulin, potentially severe side effects were abundant, and alternative ways to produce insulin were needed. This case study guides students through the history of using insulin to treat diabetes, focusing on the development of recombinant DNA technology and the world's first bioengineered drug, recombinant human insulin, which is now used worldwide to treat diabetes. Through the course of this case, students consider the central dogma of molecular biology, the development of recombinant DNA technology, drug design, the importance of recombinant proteins to our society, and the ethical analysis and debates that occur as a result of some scientific discoveries. This case was developed as an introduction to an upper-division biotechnology course focusing on recombinant protein design and production, but could also be used in molecular biology, biochemistry, or introductory biology courses to highlight recombinant DNA and biotechnology.


Objectives

  • Define diabetes and describe how insulin is used as a treatment.
  • Describe the historical developments of recombinant DNA technology and recombinant insulin.
  • Draw and outline the basic steps used to create a recombinant protein.
  • Evaluate the use of recombinant DNA technology in terms of the potential risks and rewards.
  • Justify why recombinant proteins are essential to medicine and the pharmaceutical and biotechnology industries.

Keywords

Recombinant DNA; recombinant protein; insulin; diabetes; drug design

Topical Areas

Ethics, History of science, Regulatory issues

Educational Level

Undergraduate lower division, Undergraduate upper division

Format

PDF

Type / Methods

Directed, Discussion, Interrupted

Language

English

Subject Headings

Biotechnology  |   Cell Biology  |   Molecular Biology  |   Biochemistry  |   Physiology  |   Medicine (General)  |   Public Health  |   Pharmacy / Pharmacology  |   Biology (General)  |  


Date Posted

5/29/2013

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