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Woe to That Child

A Case of Cystic Fibrosis


Author(s)

Dayton J. Ford
Pharmaceutical Sciences
St. Louis College of Pharmacy
dford@stlcop.edu

Abstract

Alvin’s parents are worried about him. He has had a cough for almost a week, and he’s wheezing a lot more than they think is normal for a child with a cold, which is what their family pediatrician says he has. When they take him to the ER, however, the pediatric pulmonologist on duty tells them their son is suffering from something much more serious than a cold. This case study was developed for second-year pharmacy students to help them tie together elements of cell physiology, osmosis and tonicity, and membrane transport processes. The questions, which focus on disease mechanisms, symptoms, and treatment options, could be modified for  non-pharmacy students.


Objectives

  • Describe basic mechanisms of genetic inheritance, specifically the difference between a recessive and a dominant trait.
  • Describe the mechanism for protein synthesis including transcription, translation, and modification within the Golgi apparatus.
  • Describe how alterations in membrane transport may affect the tonicity of the extracellular fluid (ECF).
  • Explain in detail the mechanism whereby altering ECF solute concentrations can alter the water composition of the ECF.

Keywords

Cystic fibrosis; genetic disease; autosomal recessive disease; cystic fibrosis transmembrane conductance regulator; CFTR channels; extracellular fluid; membrane transport; osmosis; tonicity; Golgi; genetic inheritance; gene therapy

Topical Areas

N/A

Educational Level

Undergraduate upper division, Graduate, Professional (degree program), Clinical education

Format

PDF

Type / Methods

Directed

Language

English

Subject Headings

Physiology  |   Cell Biology  |   Biology (General)  |   Medicine (General)  |  


Date Posted

03/17/03

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Comments


Linda Nobles
lnobles@jackson.k12.ms.us
Science
Forest Hill High School
Jackson, MS
03/10/2011
Great case study!

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