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A Botched Botox Party in the Hamptons

This flipped case study explores how the topics of membrane structure, transport, and signaling via membrane-bound receptors are intimately associa ...


A Cure for Cancer?

This flipped case study begins with a video in which a student reveals a family member's diagnosis with breast cancer and then considers the whirlw ...


A Devil of a Disease

Since its first recorded appearance in 1996, Tasmanian Devil Facial Tumor Disease (DFTD) has wiped out an estimated 70 percent of the Tasmanian dev ...


A Diet to Die For

This clicker case is designed to lead students to a conceptual understanding of oxidative phosphorylation (and, by analogy, photosynthesis). Studen ...


A Different Kind of Stress

Protein folding and trafficking is essential for normal cell function, and when it goes awry it can lead to various chronic conditions, including f ...


A Metabolic Storm

This "clicker" case presents the true story of a 20-year-old athlete who developed a life threatening reaction to anesthesia during a simple electi ...


A Rainbow of Sepia

This flipped case study examines the selective pressures that have affected the evolution of diverse human skin pigmentations. To prepare for the c ...


A Rough Semester

This interrupted case study tells the story of Katie, an active college sophomore who experiences flu-like symptoms.  She initially thinks tha ...


African Illness: A Case of Parasites?

This case is based on a British patient presenting to a hospital with an array of symptoms after returning from an African safari. Students learn a ...


Agony and Ecstasy

This “clicker case” follows Susan, an intern at a local hospital, who has admitted a patient she discovers has used the drug Ecstasy. T ...


Am I a Girl, or a Boy?

A baby is born with ambiguous genitalia to parents from the Dominican Republic and is determined to be a female based on general appearance.  ...


Apple and Linguine

This flipped case study is suited for general education undergraduate level biology. Students prepare ahead of time for class by viewing a video cr ...


Baby Doe v. The Prenatal Clinic

This "clicker case" presents a fictionalized story about a couple ("John" and "Jane") whose new baby is born with Down syndrome; the parents are su ...


Bad Fish, Bad Bird

This "clicker case" is based on the General Biology edition of James Hewlett’s “Bad Fish” case in our collection. The case follow ...


Bad Fish: Cell and Molecular Biology Edition

In this version, developed for classes in cell and molecular biology, the protagonist of the case, Dr. Westwood, survives an accidental poisoning-n ...


Bad Fish: General Biology Edition

In this version, developed for a course in general biology, the protagonist of the case, Dr. Westwood, survives an accidental poisoning-not once, b ...


Brain Workouts

This directed case study follows two college roommates, Darrell and Anthony, who have just returned to school after winter vacation. They share tha ...


Bringing Back Baby Jason

This dilemma case, designed for use in an undergraduate genetics course, explores the basic genetic concepts underlying the cloning process as well ...


But I'm Too Young!

In this “clicker case,” students are introduced to Abby, a college student who has been diagnosed with ovarian cancer. As they follow A ...


CAR T Immunotherapy

This directed case study was written to help students learn about an innovative cancer therapy that harnesses a patient's immune system to recogniz ...


Ciara’s Struggle

This interrupted case study follows Abby and her husband Jim who have recently adopted a young girl, Ciara. Ciara was homeless prior to the adoptio ...


Classic Experiments in Molecular Biology

All introductory biology textbooks, and many sophomore-level genetics textbooks as well, describe several classic experiments in molecular biology. ...


Cross-Dressing or Crossing-Over?

In this “clicker case,” students learn about sex determination, meiosis, and chromosomal “crossing over” through the story ...


Cystic Fibrosis

This PowerPoint-driven, flipped case study begins with a short video about a woman suffering from cystic fibrosis (CF) in the 1970s, a friend of th ...


Death Becomes Us

This interrupted case study reviews the cellular and molecular mechanisms involved in apoptosis, or programed cell death, and how it may be used in ...


Diabetes and Insulin Signaling

Cellular signaling, otherwise known as signal transduction, is the mechanism by which cellular context and environmental situation are used to regu ...


Diagnosing and Treating Charlie’s Strange Spots

This case study introduces a patient who comes into a doctor's office with an interesting set of symptoms that leads to an exotic cancer diagnosis. ...


Earthquakes Damage Cells, Too

Cholera is a commonly explored disorder when teaching transmembrane transport. Expanding on this theme, this case study also introduces intracellul ...


Evolution in Action

This case study is based on Dr. Richard Lenski’s ongoing studies of evolution in E. coli. Students are introduced to prokaryotic bio ...


Face the Fats

This clicker case introduces students to the biochemistry of lipids through the story of Pete, a college student who begins to consider his nutriti ...


From Cow Juice to a Billion Dollar Drug, With Some Breakthroughs in Between

Before the discovery of insulin in 1921, being diagnosed with Type 1 diabetes was a death sentence. Despite the successful management of diabetes w ...


From Gummy Bears to Celery Stalks: Diffusion and Osmosis

This is an interrupted case study that intersperses information about diffusion and osmosis with content review and knowledge application questions ...


From Twiggy to Tubby

This case study explores the topics of diffusion, osmosis, membrane transport, and the physiological significance of glucose and insulin in the hum ...


Genetic Testing

This case study centers on “Tom,” a 43-year-old male patient, and his recent genetic sequencing results and diagnosis of multiple endoc ...


Hidden in Plain Sight

As nonliving entities, viruses face specific challenges when replicating in a host.  Avoiding the host immune system is something that every v ...


Holes in the Matter

This case centers on a fictional group of young adults who studied abroad together in Scotland as college students. A number of them develop diseas ...


Host-Pathogen Interactions

This case study introduces students to the complex field of immunology and the wide variety of host-pathogen interactions that drive evolutionary c ...


How to Make ATP

This case study for the flipped classroom introduces the discovery process used to elucidate how cells make ATP. Data from three seminal primary li ...


I Hate Running!

This interrupted worksheet case study, developed for introductory or intermediate undergraduate physiology courses, aims to eliminate misconception ...


I Scream for Ice Cream

Lactose intolerance, caused by a lack of persistent lactase enzyme expression, is a trait commonly observed in adult humans, with varying geographi ...


In Search of a Cure for Breast Cancer

In this directed case study, students analyze data, draw a research-based conclusion, interpret experimental results, and discuss the relevance of ...


It’s All Greek to Me: Genetics Edition

Stephania and Nikolaus Stamos are concerned about their baby daughter. They take her to her pediatrician, who immediately notices that the once bri ...


Jim and the Forgotten Embryos

The goal of this case study is to expose students to the basics of embryonic stem cells, their therapeutic uses, and the controversy surrounding em ...


Joel E. Greengiant Learns About Peas

This case study follows purveyors of peas, Joel E. and Jolene Greengiant, as they learn about the origin, biochemistry, genetics and eventual artif ...


Know Your Enemy, Know Yourself

This case study relates the actual experiences of a woman with breast cancer as she shares her experiences through a series of blog posts at variou ...


Lee Family Problems: The Yin and Yang of Membrane Physiology

This interrupted case study follows "Elaina Lee" and her family through a series of medical mishaps. Elaina suffers a reaction to an overdose of an ...


Little Girl Lost: A Case Study on Defective Cellular Organelles

This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases ...


Little Mito

This case presents a fanciful story about the origin of the eukaryotic cell, a major milestone in the evolution of life. The characters of the stor ...


Magic Bullets

This clicker case was designed to teach students about basic enzyme structure, mechanisms of enzyme inhibition, and mechanisms of drug resistance. ...


Make a Life to Save a Life

In this “clicker case,” students learn about meiosis through the real-life story of a couple who used pre-implantation genetic screenin ...


Metabolism Out of Control

Cancer is a complex and varied group of diseases. There are, however, several common characteristics among all cancers. For example, it has been kn ...


More Than Just a Cough: Exploring the Role of the Cytoskeleton in Fertility

This interrupted case study explores the role of cytoskeletal structures on human health, specifically on respiratory function, sperm motility, and ...


Mother's Milk Cures Cancer?

This case study on the immune system, cell cycle regulation, and cancer biology explores the role that serendipity plays in new discoveries in scie ...


mRNA Processing

This clicker case study follows a dialogue between two college students, Lucy and Dan, as they discover how alternative splicing of mRNA molecules ...


My Dog is Broken!

Cell signaling is one of the more difficult concepts for students to understand in their study of cell biology. To help students better understand ...


New Ways to Breathe

This case study follows a young cystic fibrosis (CF) patient named Lucas. Through Lucas's story and interactions between his parents and pediatrici ...


Newsflash! Transport Proteins on Strike!

This role-play case study teaches students about plasma membrane transport and the functions of transport proteins in the phospholipid bilayer. Stu ...


No Matter If You’re Black or White

Human populations have adapted to varying intensities of sunlight with varying tones of skin coloration. The balanced interplay between melanin con ...


Oh, What a Difference a Carbon Can Make!

Sarah, trapped in the middle of a two-hour lecture on enzyme inhibition, attempts to escape by asking a question. She relates an old story she hear ...


One Tablet a Day May Keep Cancer Away

This dilemma/decision case study is intended to demonstrate how knowledge of signal transduction pathways can be applied to the pharmaceutical indu ...


Oral Allergy Syndrome

Students who work through this case study will follow the progress of “Sam” as he explores the microbiological mechanism of oral allerg ...


Osmosis is Serious Business!

This directed case study involves two “stories,” each one concerned with some aspect of osmosis in living cells. Part I is centered aro ...


Osmosis is Serious Business! Hebrew Translation

This directed case study, translated from the original English into Hebrew, involves two “stories,” each concerned with some aspect of ...


Pharmacogenetics: How Genetic Information Is Used to Treat Disease

In this clicker case, two teenagers are diagnosed with Acute Lymphoblastic Leukemia (ALL), a cancer of the bone marrow where there is an abnormal o ...


Poor Devils

Cancer is usually thought to be a disease that affects individuals. But could cancer evolve to become infectious? This case follows the research on ...


Protein Targeting Gone Awry

This case study synthesizes students' knowledge of the central dogma and cell structure by examining a rare health disorder in order to understand ...


Resistance is Futile - Or Is It?

While the majority of people are prone to HIV infection, some individuals remain uninfected despite repeated exposure. This case study is based on ...


Resistance Is Futile, Or is It? The Clicker Version

This clicker case is an adaptation of a case by Annie Prud'homme-Généreux that was originally published by the National Center for Ca ...


Rhabdomyolysis

This directed case study focuses on exercise-induced rhabdomyolysis (exRML).  Students are guided though skeletal muscle cell membrane transpo ...


Saving Superman

Using a combination of directed case method and role-playing in which students learn about their roles using the jigsaw technique, this case study ...


Scorpion vs. Mouse

This flipped clicker case study explores the fascinating relationship between the Arizona Bark Scorpion (the most venomous scorpion in North Americ ...


Sex and the Komodo Dragon

In this clicker case study for a flipped classroom, students familiar with the stages of meiosis work in small groups to determine the predicted ge ...


Sickle Cell Anemia

In this case study on sickle cell anemia, students are introduced to some of the key researchers responsible for determining the molecular basis of ...


Snow White Apples?

The protagonist of this two-day flipped case study, “Maria,” has two problems. She doesn’t like it when the apple slices in her l ...


Sonic Hedgehog

In this case study about a baby born with the genetic condition holoprosencephaly, students explore the “Sonic hedgehog” gene, signal t ...


Stem Cells: Promises to Keep?

Samantha and her husband Brad have two children, conceived with the help of in vitro fertilization treatments. After viewing a TV program on stem c ...


Stem Cells: Promises to Keep? Clicker Case Version

This clicker case is based upon the case "Stem Cells: Promises to Keep" written by Lauren E. Yaich and published by the National Center for Case S ...


Stomp the Stomach Bug

Norovirus is one of the most common causes of infectious diarrhea and vomiting, leading to the nickname “winter vomiting disease.” The ...


Take Two and Call Me in the Morning

In this “clicker case,” students read about a college student who becomes sick. As they set out to identify the cause of the illness, s ...


Tazswana’s Story

In this directed case study, students read about a little girl with beta-thalassemia, a life-threatening disease. Through a series of increasingly ...


The Campus Coffee Shop

Since caffeine is a widely used substance, especially by college age students, this case on the effects of caffeine on the human body serves as a r ...


The Case of Eric, Lou Gehrig's Disease, and Stem Cell Research

Thirty-one-year-old Eric has begun to show signs of the debilitating and fatal neuromuscular disease, amyotrophic lateral sclerosis, also known as ...


The Case of the Dividing Cell

The Honorable Judge Cellular is presiding over the case of The State vs.Egg Cell Number 6624223. As the prosecuting attorney calls each wi ...


The Case of the Malfunctioning Neuron

This flipped case study tells the story of Joyce, a biology student who notices the development of some unusual symptoms (foot slapping and slurred ...


The Case of the Tainted Taco Shells: Advanced Edition

This case discusses some of the issues associated with the use of genetically modified plants, including ecological risks, resistance, and allergen ...


The Challenge of Epilepsy

This case study was originally developed for undergraduate science students as part of an extracurricular competition, but it could also be deliver ...


The Curious Case of the Carbon Copy Kitty

After the media coverage of Dolly the sheep and pet cloning, most students in a general biology or general genetics course will have heard of anima ...


The Ebola Wars: Advanced Edition

This case study was written for upper level undergraduate and graduate students to review foundational aspects of virology and to examine Ebola vir ...


The Ebola Wars: Mission Immune Evasion

Through a unique anthropomorphic view and the integration of game-based learning, this case study explores how the Ebola virus can evade the immune ...


The Evolution of Color Vision in Monkeys

This case study examines the evolution color vision in Old World and New World monkeys from multiple biological perspectives. This integrative appr ...


The Evolution of Human Skin Color

While the concept of evolution by natural selection is very simple, it is often misunderstood by students. This is partly due to preconceptions the ...


The Evolving Genetics of Disease Resistance

This interrupted case study for the flipped classroom applies evolutionary genetics research to human health. Students learn about a naturally occu ...


The Interview: Hemoglobin vs. Myoglobin

This case study examines the structure of hemoglobin and myoglobin and how the structure of these molecules dictates their function. The case is wr ...


The Lady of Charleston?

This case uses the real story of Dawn Langley Simmons, who may have been misidentified as male at birth, to illustrate the developmental basis of h ...


The Mystery of the Seven Deaths

In this interrupted case study, students learn about the function of cellular respiration and the electron transport chain and what happens when th ...


The Physiology of a Neurodegenerative Disease

In this case, a young woman learns that her uncle has been diagnosed with Huntington’s disease. She talks with her fellow graduate students t ...


The Potential Perils of Pauline

This directed case study follows the story of “Pauline,” a 20-year-old college student who has just received results from a personal ge ...


The Secret of Popcorn Popping

Focusing on the important role of water in living cellular chemistry, this case emphasizes the general solubility rule, "like dissolves like," whic ...


The Unfortunate Nurse

Dengue (pronounced "deng-ee") is a viral disease transmitted by the bite of an infected mosquito, usually Aedes aegypti. It is common in ...


Those Old Kentucky Blues

This interrupted case study begins with the construction of a pedigree following an initial encounter with a clan of “blue people.” Aft ...


Three Cases from the Membrane Files

This PowerPoint-driven case study presents three different stories, each of which explores an aspect of membranes. The first (The Exploding Fish) c ...


To Be or Not to Be ... an Inhibitory Neurotransmitter

Jessica and George are students struggling to understand the forces which control ions moving across membranes.  For the nervous system in par ...


Too Many B Cells

Taylor's doctor notices she has swollen lymph nodes and an elevated white blood cell count on her routine annual exam and asks her to return for a ...


Water Can Kill?

This case study presents three true stories of people who suffered fatal hyponatremia (low sodium concentration in their body fluids) after consumi ...


What Happened to Beau?

This flipped case was designed to introduce students in a general introductory biology course to basic protein structure. The two videos and interr ...


What's Wrong with Our Son?

In this interrupted case study, students examine the fundamental connections between genotype, 3-D protein structure and phenotype by exploring pos ...


Who Killed Yew?

The purpose of this case is to teach introductory college biology students the basic process of mitosis, focusing on the fundamental cellular proce ...


Why Does Grandpa Ignore Grandma?

Carla, a first semester graduate student in audiology, has noticed that her grandfather appears to be having trouble hearing what her grandmother s ...


Why Is He Different from Both Parents?

This case study was developed to teach the topic of human ABO blood type and genetic inheritance in biology courses at the lower undergraduate leve ...


Wiggles Isn’t Wiggling: Apoptosis Edition

This case study tells the story of a family pet that is diagnosed with cancer.  Claire learns that her dog Wiggles has lymphoma, and that hist ...


Wiggles Isn’t Wiggling: Gene Expression Edition

This case study tells the story of a family pet that is diagnosed with cancer.  Claire learns that her dog Wiggles has lymphoma, and that hist ...


Woe to That Child

Alvin’s parents are worried about him. He has had a cough for almost a week, and he’s wheezing a lot more than they think is normal for ...


Wrestling with Weight Loss

In this interrupted case study, a young wrestler considers purchasing 2,4-dinitrophenol (DNP) online as a means to drop weight quickly. However, a ...


Yeast Cryptography

This "clicker case" focuses on the use of molecular biology concepts and techniques to protect the property of a fictional bread company. Students ...


You Are Not the Mother of Your Children

This case is based on a true story of a woman whose children were almost taken from her because her DNA profile indicated that she was not the moth ...


Yvette's Brave Battle

This case is based on the true story of a woman with choriocarcinoma, a rare type of rapidly dividing and metastatic cancer derived from cells of t ...