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“All Sorts of People”

This historical case study is based upon events surrounding the deadly 1721 smallpox epidemic in Boston. It recounts the story of Cotton Mather, hi ...


A “Deafinite” Cause for Alarm

“Henry” is not the best of patients. He has been admitted into the hospital with bacterial pneumonia, but he soon becomes bored and fru ...


A Bad Reaction

This case involves the transfer of a food allergy to a patient who received a combined kidney and liver transplant from a donor who died as the res ...


A Botched Botox Party in the Hamptons

This flipped case study explores how the topics of membrane structure, transport, and signaling via membrane-bound receptors are intimately associa ...


A Case in Point: From Active Learning to the Job Market

This case was developed for use in the first weeks of a course in order to show students how participating in active learning exercises in their cl ...


A Case of Acute Pancreatitis

The pancreas is the source of the bulk of digestive enzymes that act upon the contents of the small intestine. The normal function of the pancreas ...


A Case of Cerebrovascular Accident

"Samuel Dexter" is 52 years old, overweight, and a heavy smoker. He wakes one morning with weakness on his right side.  When he attempts to wa ...


A Case of Diabetes Insipidus

“Amanda Richards,” a 20-year-old junior in college, is majoring in biology and hopes to be a pediatrician one day. For about a month, s ...


A Case of Iron Deficiency Anemia

“Dolores Welborn,” a 28-year-old attorney, is pregnant with her first child. Lately she has been tiring easily and is often short of br ...


A Case of Neurocardiogenic Syncope

“Allison Jacobson” is a 19-year-old sophomore majoring in pre-med. The past few weeks she has been studying for finals. She feels tired ...


A Case of Pharyngitis

Seven-year-old “Jason Hornbuckle” has been complaining for the past 12 hours of pain when he swallows.  He also has a headache and ...


A Case of Spinal Cord Injury

“Jason Hendrix,” a 21-year-old student majoring in economics, is injured in a serious motorcycle accident while on spring break in Flor ...


A Case of Thrombocytopenia

“Carolyn Jones” is a 40-year-old professor of economics. The past week she has felt tried and weak. The past few days she has noticed s ...


A Case of X-linked Agammaglobulinemia

Though a normal, full-term baby at birth, starting at about 10 months of age “Billy DeWitt” has suffered a series of infections, includ ...


A Case Study Involving Influenza and the Influenza Vaccine

This interrupted case study presents a discussion about the benefits of the influenza vaccine between Mary, a nursing student, and her coworker, Ka ...


A Case Study of Memory Loss in Mice

This discussion case explores the scientific process involved in implementing an animal model in the study of Alzheimer’s disease. Students r ...


A Cure for Cancer?

This flipped case study begins with a video in which a student reveals a family member's diagnosis with breast cancer and then considers the whirlw ...


A Difficult Pregnancy

This case study, about a developmentally disabled, 30-weeks-pregnant 19-year-old, presents some of the patient management issues that health care w ...


A Family in Need: In-Class Case Study on Cancer Genetics

This case is designed as an in-class, problem-based learning activity for students to learn about several innovative medical applications of molecu ...


A Family in Need: Internet-Enhanced Case Study on Cancer Genetics

This problem-based learning case was designed for students to learn about several innovative medical applications of molecular biology. Students as ...


A Grumpy Old Man

This directed case study tells the story of an 84-year-old man who has been brought to the ER for treatment of a badly broken wrist. Routine bloodw ...


A Healthy Retirement?

Nancy has been looking forward to her retirement and a chance to entertain and travel with her husband Jim. But she hasn’t been feeling well. ...


A Metabolic Storm

This "clicker" case presents the true story of a 20-year-old athlete who developed a life threatening reaction to anesthesia during a simple electi ...


A Need for Needles - Acupuncture

In this case study, students evaluate information about the use of acupuncture and consider the possibilities of alternative therapies while at the ...


A Pain in the Gut

This interrupted case study in gastric physiology follows the story of Frank, a businessman under a lot of stress who has a car accident while driv ...


A Perfect Storm in the Operating Room

In this interrupted case study, a high school biology student shadows her uncle, an anesthesiologist, at a hospital for a school assignment. She wi ...


A Rainbow of Sepia

This flipped case study examines the selective pressures that have affected the evolution of diverse human skin pigmentations. To prepare for the c ...


A Recipe for Invention

In this case study, designed to help break down stereotypes about scientists and engineers, students research the personal and professional lives o ...


A Rough Semester

This interrupted case study tells the story of Katie, an active college sophomore who experiences flu-like symptoms.  She initially thinks tha ...


A Search for the Right Answer

In this role-playing case study on Parkinson’s disease, students learn about brain injury and brain repair mechanisms, the physical and psych ...


A Shot in the Arm or a Hard Pill to Swallow?

The immune response to a vaccine is influenced by the nature of the vaccine and the delivery method. In this interrupted case study, students trave ...


A Sickeningly Sweet Baby Boy

When a newborn develops symptoms eerily similar to those of an older sibling who died shortly after birth, his Mennonite parents are understandably ...


A Simple Plan

This case study introduces students to Dr. E.L. Trudeau, who performed a seminal early experiment validating the germ theory of infection. Part I i ...


A Spill at Parsenn Bowl

Based on a real incident, this case features an older woman who has been injured on a ski slope. Her classic knee injury, often referred to as the ...


A Tradesman’s Journey Back from a Cerebral Incident

This directed case study tells the story of a middle-aged man with hypertension and hyperlipidemia who experiences an ischemic cerebrovascular acci ...


A Tragic Finding

This interrupted case study utilizes real patient data and provides students an opportunity to apply knowledge of human metabolism and hormonal con ...


A Trip to the Eye Doctor

This directed case study follows a young woman, Samantha, on a routine visit to her eye doctor.  While at her appointment, Samantha receives p ...


A Yellow-Bellied Lawyer?

This interrupted case study tells the story of Michael, a Harvard law graduate with a stressful job and a seemingly heavy drinking problem. Student ...


African Illness: A Case of Parasites?

This case is based on a British patient presenting to a hospital with an array of symptoms after returning from an African safari. Students learn a ...


Agony and Ecstasy

This interrupted case study explores the scientific, legal, and societal complexities of repurposing an illicit substance, 3,4-methylenedioxymetham ...


Agony and Ecstasy: Cell Membrane Structure and Function

This “clicker case” follows Susan, an intern at a local hospital, who has admitted a patient she discovers has used the drug Ecstasy. T ...


AIDS and the Duesberg Phenomenon

Renowned virologist and member of the prestigious National Academy of Science, Peter Duesberg has argued that AIDS is not caused by HIV, but is the ...


All or Nothing

In this interrupted case study, students pose as an intern of a neuromuscular/skeletal specialist and discover how sarin and myasthenia gravis infl ...


Am I a Girl, or a Boy?

A baby is born with ambiguous genitalia to parents from the Dominican Republic and is determined to be a female based on general appearance.  ...


Am I Going to Die?

In this directed case study students follow a 16-year-old athlete as her mild upper respiratory infection progresses to an acute respiratory illnes ...


Amber's Secret

This problem-based case focuses on the female menstrual cycle and early stages of pregnancy of an unwed teenager. Working in small groups, students ...


An Acrid Situation

This directed case study tells the story of a geriatric patient who has recently been diagnosed with idiopathic pulmonary fibrosis. It begins with ...


An End to Ulcers?

This “clicker case” teaches students about the scientific method by following the story of the discovery of the cause of human gastric ...


An Infectious Cure

This four-part interrupted case on phage therapy was developed for a freshmen non-majors course in molecular biology. The case begins with a story ...


An Unexpected Loss

This clinical case study follows the progress of a diabetic patient, “Joe,” who develops an infection and ultimately undergoes a lower ...


An Unusual Case of Hypertension

This case study examines the interaction between the endocrine, cardiovascular and renal systems. The case narrative details Mr. Smith's high blood ...


Analyzing Clinical Literature

Reading and understanding scientific literature can be a daunting task for students in introductory science courses. This decision/dilemma case stu ...


Andrea: The Death of a Diabetic

In chronicling the life and death of a woman who developed diabetes as a teenager, this case study explores such basic science topics as metabolism ...


Antibiotic Resistance

Resistance to antibiotics arose very shortly after these "wonder drugs" were first introduced.  This case study examines resistance to the mos ...


Antibiotic Resistance in a Russian Prison

In this case study, students will have the opportunity to model the spread of tuberculosis and development of antibiotic resistance in a hypothetic ...


Anxiety Doesn’t Work

This case study tells the story of Mo, an individual with social anxiety disorder who seeks mental health treatment. The purpose of this case is

Anyone Who Had a Heart

After undergoing a fertility procedure, a 37-year-old woman and her husband are expecting twins. The delivery goes smoothly, but it soon becomes ap ...


Are Vaccines and Autism Linked?

This case study was written to reinforce the understanding that a successful hypothesis accounts for all relevant observations and is falsifiable t ...


Asthma Attack!

This interrupted case study follows the progress of a pediatric patient who experiences an acute asthma exacerbation brought on by an environmental ...


Baby Doe v. The Prenatal Clinic

This "clicker case" presents a fictionalized story about a couple ("John" and "Jane") whose new baby is born with Down syndrome; the parents are su ...


Bad Blood

The ethics of human experimentation are explored in this case about the infamous syphilis studies performed at the Tuskegee Institute from the 1930 ...


Barbara’s Thyroid

This directed case study on thyroid dysfunction was written to help students understand how negative feedback pathways work. The title character su ...


Black and Blue with Love

In this directed case study students follow a nurse practitioner and work with a diagnostics team to determine what is wrong with Tristan, an infan ...


Blake's Illness

Blake is sick.  With his background in the sciences and a little help from the Internet, he should be able to do a self-diagnosis.  Or ca ...


Bloodline: A Human Genetics Case

In this "clicker" case, based on a TV drama about a family secret that only knowledge of genetics can solve, students apply what they have read and ...


Born for Recovery: The Effects of Maternal Methadone Use on Neonates

This interrupted case study presents the story of "Jane Paul," a 27-year-old pregnant woman excited by the prospect of bringing a new life into the ...


Brain vs. Spinal Cord

In this case study, students read about the injuries sustained by a young man hurt in a serious diving accident. To solve the case, they must deter ...


Bringing Home More than a Medal

This case study was inspired by the Zika virus outbreak that occurred around the time of the 2016 Olympic Games. Many athletes were fearful of atte ...


But I'm Too Young!

In this “clicker case,” students are introduced to Abby, a college student who has been diagnosed with ovarian cancer. As they follow A ...


Buzz Off!

This case study was written to teach students about malaria, an infectious disease transmitted by the female Anopheles mosquitoes that thr ...


CAMEL Question: Can Applied Math Extend Life?

This directed case study examines differences between the exponential and logistic growth models in biology and how they are applied to solve real ...


Can a Genetic Disease Be Cured?

In this discussion case, parents must decide whether or not to enroll their sons in an experimental treatment program designed to alleviate the sym ...


CAR T Immunotherapy

This directed case study was written to help students learn about an innovative cancer therapy that harnesses a patient's immune system to recogniz ...


Cardiac Blood Flow

This interrupted case study tells the story of a middle-aged female, “Josie,” who receives a diagnosis of congestive heart failure. In ...


Caught Red-Handed

Was the "Brooklyn Butcher" of 1926 a cold-blooded killer or was something less sinister at play? This interrupted case study introduces students to ...


Chemical Eric

This case study is designed to teach introductory biology majors about the role of the pituitary in controlling hormones. It could easily be applie ...


Chemical Eric Can't See

This autobiographical case study presents the story of Eric as he learns that he has a genetic eye disease, which progresses to the point that he b ...


Chickens and Humans and Pigs, Oh My!

Influenza is a common topic in the popular press and a point of interest for many students.  This case study was written to promote interdisci ...


Childbed Fever

This case describes the pioneering work of Ignaz Semmelweis and his efforts to remedy the problem of childbed fever in mid-19th century Europe.&nbs ...


Cholera and Conflict in Yemen

This case study explores the 2016–2018 cholera outbreak in Yemen and how political and financial circumstances impacted relief efforts. Stude ...


Coronavirus Quandaries for Patients with Cardiovascular Disease

This directed case study tells the story of “Arie,” an anatomy and physiology student who has recently switched to distance learning du ...


Cracking the Case

In this directed case study, students shadow Dr. Lee in diagnosing two patients with osteoporosis. The students are given patient history and an in ...


Danielle's Difficulty

The incidence of Clostridium difficile infection (CDI), including severe infection, has increased in both institutional settings and the g ...


Dengue in the Landscape

This interrupted case engages students in issues contributing to the increase of dengue fever in Jamaica. The overall goal of the case is to make c ...


Diabetes and Acid/Base Chemistry

This case study focuses on a teenage patient with type 1 diabetes mellitus (T1DM) who presents with severe acidosis, becomes combative and loses co ...


Diabetes and Insulin Signaling

Cellular signaling, otherwise known as signal transduction, is the mechanism by which cellular context and environmental situation are used to regu ...


Diagnosing and Treating Charlie’s Strange Spots

This case study introduces a patient who comes into a doctor's office with an interesting set of symptoms that leads to an exotic cancer diagnosis. ...


Diagnosis of a Congenital Disorder

This progressive disclosure case study explores the medically-related issues of a female infant born with the congenital disorder Sirenomelia, more ...


Differential Diagnosis and Treatment of an Autoimmune Response

There are a number of medical disorders that mimic each other and accordingly prove problematic for diagnosis, including autoimmune disorders (rheu ...


Disease Along the River: A Case Study and Cholera Outbreak Game

This case study centers on an active teaching game that simulates a cholera outbreak among five villages along a river, similar to the Haitian outb ...


Does a One-Size Drug Dose Fit All?

The purpose of this case study is to make students aware that some patients may require individualized drug dosing regimens based on a variety of p ...


Driving Can Be Dangerous to Your Health

In this interrupted case study, students read about an older woman named Barbara who becomes ill after driving with her husband 19 hours from Flori ...


Drug Wars: An Epic Tale of Asthma and Bacterial Pneumonia

This case study is based on real events that the author experienced with her 10-year-old daughter. Although the names have been changed, all of the ...


Earthquakes Damage Cells, Too

Cholera is a commonly explored disorder when teaching transmembrane transport. Expanding on this theme, this case study also introduces intracellul ...


East Meets West

Ying is sick and is progressively getting worse. His parents' clashing views on Eastern and Western medicine prevent them from agreeing on a course ...


Ellen's Choice

This case encourages students to explore various aspects of alternative and complementary medicine that might be helpful in treating a woman who is ...


Enigma in the ED

This PowerPoint-driven case study has students apply the “Steps of an Outbreak Investigation” from the Centers for Disease Control and ...


Ethnomedicine in Latino Communities of Madison

This PowerPoint-delivered case study guides the reader, a hypothetical student intern with the City of Madison (Wisconsin) Public Health Department ...


Eyes Without a Face

Although blind since childhood as the result of an accident, Lucy has never given up hope that one day she might see again. So, when her ophthalmol ...


Facing the Pain

This interrupted case study in cardiovascular and nerve physiology focuses on Lynn, a married woman with a young child whose husband is often awa ...


Family, Culture, Medicine

This four-part problem-based learning case examines cultural conflicts between Western medicine and non-Western traditional healing practices. Stud ...


Feeling Detoxified

This case study uses the example of ionic foot baths to examine how placebo treatments can affect our health and wellness. Inspired by a student&rs ...


Fluid in the Ear

This interrupted case study follows the progress of Julius, a singer in a rock band who suffers from severe headaches and pressure in his ears. Whi ...


From Cow Juice to a Billion Dollar Drug, With Some Breakthroughs in Between

Before the discovery of insulin in 1921, being diagnosed with Type 1 diabetes was a death sentence. Despite the successful management of diabetes w ...


From Tackle to Tension Pneumothorax

Tension pneumothorax is a condition that is associated with air in the pleural space. In this case study, tension pneumothorax is caused by a ruptu ...


From Twiggy to Tubby

This case study explores the topics of diffusion, osmosis, membrane transport, and the physiological significance of glucose and insulin in the hum ...


Genetic Testing and Breast Cancer

In this dilemma case, the central character, Kathy, must decide whether or not to be tested for known mutations in the breast cancer genes. Student ...


Giant Pandas, Hormones, and the Evolution of a Lazy Bear

This clicker case study looks at the role of hormone cascades in homeostatic control of metabolism in a charismatic organism, the Giant Panda.  ...


Girl Pulled Alive from Ruins, 15 Days after Earthquake

This case examines the integrated physiological response to dehydration and starvation from the real-life report of a girl discovered 15 days after ...


Going for Gold

This case study introduces students to the true story of Caster Semenya, an outstanding female mid-distance runner from South Africa.  Caster ...


Headaches, Mood Swings, and Dropping Things

This interrupted case study walks students through the stages of determining a diagnosis for a neural condition/disease in a 62-year-old female. Th ...


Helicobacter pylori and the Bacterial Theory of Ulcers

This case is an account of the events that led Drs. Robin Warren and Barry Marshall to the bacterial theory of ulcers. The two physicians refused t ...


Hemophilia

This case deals with the genetics of the hemophilic condition that afflicted the royal families of Europe.  Students trace the pedigrees of th ...


Hidden in Plain Sight

As nonliving entities, viruses face specific challenges when replicating in a host.  Avoiding the host immune system is something that every v ...


Holes in the Matter

This case centers on a fictional group of young adults who studied abroad together in Scotland as college students. A number of them develop diseas ...


Honeymoon Havoc

In this interrupted case study, students meet a pair of fictional newlyweds on their way to Australia for their honeymoon. Initially eager to enjoy ...


Host-Pathogen Interactions

This case study introduces students to the complex field of immunology and the wide variety of host-pathogen interactions that drive evolutionary c ...


Hot and Bothered

This interrupted case study is a story about Carrie and her infant daughter Hayden who share similar symptoms: weight loss, metabolic abnormalities ...


How a Cancer Trial Ended in Betrayal

In this case study, students learn about the complexities and issues associated with clinical trials. After reading a newspaper story about a fraud ...


Hunting the Ebola Reservoir Host

This one-hour introduction to the study of infectious diseases uses recent research on the Ebola reservoir host to motivate students to consider th ...


Hyper-IgM Syndrome

Hyper-IgM syndrome is an X-linked genetic disorder more commonly affecting males than females. It is caused by the lack of heavy chain class-switch ...


I've Fallen Over and I Can't Get Up

Greg Myron is playing the last football game of his career as the high school’s star running back. As the clock counts down the final seconds ...


Indigenous Knowledge and the Search for Medicine

This case study is based on a real scenario in which a high-profile ethnobotanical study in Chiapas, Mexico, ended when local and international org ...


Is That Pill You're Taking Safe?

This dilemma cased is based on the actual development, FDA approval, and market withdrawal of dexfenfluramine, a drug used in the late 1990s in com ...


Is the Data Dirty or Clean?

This case study challenges students to differentiate between anecdotal evidence and science-based evidence related to human health. The case uses a ...


Is There a Relationship Between Blood Type and Risk of Contracting COVID-19?

This directed case study introduces the basics of blood typing and discusses possible correlations for contracting COVID-19 by blood type. After st ...


It Takes a Herd

This directed case study places students in the role of committee members tasked with developing a strategic long-term plan for building up herd im ...


It's Just Stress, Right?

Ellie is a struggling college student on the brink of failing her physiology course; not surprisingly, she exhibits many classic signs of stress. H ...


It’s All Greek to Me: Genetics Edition

Stephania and Nikolaus Stamos are concerned about their baby daughter. They take her to her pediatrician, who immediately notices that the once bri ...


Josie

In this interdisciplinary case, students meet Josie, the main character, who suffers from a variety of symptoms. Students must grapple with the con ...


Kate-tastrophy

In this interrupted case, students examine the concept of unconsciousness and develop an understanding of how clinicians diagnose death. Developed ...


Know Your Enemy, Know Yourself

This case study relates the actual experiences of a woman with breast cancer as she shares her experiences through a series of blog posts at variou ...


Lacy’s Dry Run

This interrupted case study in renal physiology and water balance follows the story of "Lacy," a star athlete, who makes poor fluid intake choices ...


Living in a Genomic World

This directed case study was developed in order to present genomic data to students, allow them to interpret the impact of genetic variations on ph ...


Living the Sweet Life

In this directed case study, students help “Dr. Gupta” diagnose three patients in an endocrinology clinic who are having problems with ...


Magic Bullets

This clicker case was designed to teach students about basic enzyme structure, mechanisms of enzyme inhibition, and mechanisms of drug resistance. ...


Make a Life to Save a Life

In this “clicker case,” students learn about meiosis through the real-life story of a couple who used pre-implantation genetic screenin ...


Mark’s Failing Heart

This directed case study centers on the story of a 65-year-old man with a weakened ventricle, resulting in reduced cardiac output. Students are pro ...


Mary Keeper’s Aching Head

In this problem-based learning case, students read about a 41-year-old woman who is suffering from recurring headaches. Working in small groups, th ...


MDR Tuberculosis

In this case study on multi-drug resistant (MDR) tuberculosis, students consider ways in which to preserve health as a human right without subjecti ...


Morgan: A Case of Diabetes

This case teaches about the causes and effects of Type 2 diabetes by working through the various options available to a young Native American woman ...


MRSA in the NICU

DNA sequencing and analysis (bioinformatics) is an increasingly important tool for understanding biological data, including medical data. In this c ...


Needles and Pins

This case, designed for medical students, dental students, and dental hygiene students, covers the steps involved in preventing and responding to a ...


New Ways to Breathe

This case study follows a young cystic fibrosis (CF) patient named Lucas. Through Lucas's story and interactions between his parents and pediatrici ...


No Longer Living the Sweet Life

In this interrupted case study, students will help “Dr. Gupta” investigate and assess complications arising in one of her long-term pat ...


Not an Old Person's Disease

The overall goal of this case is to introduce students to the genetic basis of cancer while teaching them about melanoma. The fictional protagonist ...


Not Exactly...

This case study follows a young couple that is consulting with a genetic counselor about their plans to have a child. Because of their family histo ...


Not Just Another Day at the Beach

Students read about a case of melanoma that occurred over 10 years ago and then discuss issues faced by cancer patients and their families in makin ...


Oh, What a Difference a Carbon Can Make!

Sarah, trapped in the middle of a two-hour lecture on enzyme inhibition, attempts to escape by asking a question. She relates an old story she hear ...


One Headache After Another: Biochemistry Edition

Topamax®, developed to treat epilepsy, is also used as a preventative for migraine. In this case study, students read about a woman experiencin ...


One Headache After Another: Physiology Edition

Topamax®, developed to treat epilepsy, is also used as a preventative for migraine. In this case study, students read about a woman experiencin ...


Osteoporosis

This directed case study focuses on the physiology of bone homeostasis and methods of prevention and treatment of osteoporosis. One of the overall ...


Patient Zero

Emerging diseases and potential pandemics make the news nearly every year. Students (and everyone else) may wonder where new infectious diseases co ...


Pharmacogenetics: How Genetic Information Is Used to Treat Disease

In this clicker case, two teenagers are diagnosed with Acute Lymphoblastic Leukemia (ALL), a cancer of the bone marrow where there is an abnormal o ...


Pharmacogenetics: Using Genetics to Treat Disease

This case study investigates the applications of genetics to medicine by exploring one of the first examples of a pharmacogenetic test to enter mai ...


Resistance is Futile - Or Is It?

While the majority of people are prone to HIV infection, some individuals remain uninfected despite repeated exposure. This case study is based on ...


Resistance Is Futile, Or is It? The Clicker Version

This clicker case is an adaptation of a case by Annie Prud'homme-Généreux that was originally published by the National Center for Ca ...


Retro Goes Modern

This case study considers the evolution of HIV from SIV, as well as the evolution of HIV within humans by mutation rate. It also discusses the immu ...


Return of the Whoop!

This interrupted case study outlines the history of pertussis or whooping cough, a disease that in the early 1900s claimed the lives of more people ...


Revolt on the Tuberculosis Ward

Monique is a 30-year-old Haitian woman with advanced pulmonary tuberculosis who has been transferred from a tuberculosis sanatorium to a large gene ...


Rhabdomyolysis

This directed case study focuses on exercise-induced rhabdomyolysis (exRML).  Students are guided though skeletal muscle cell membrane transpo ...


Running Off Track

This interrupted case study follows the course of Cara, a high school athlete training for the state championships in cross country. She suffers fr ...


Sarah's Sickness

This story is based on the true account of a student who suffered years of misdiagnoses of her illness while she was in a professional school. As t ...


Saving Superman: Ethics and Stem Cell Research

This case explores the political and ethical issues associated with stem cell research. Students read the case describing Christopher Reeve’s ...


Sex and Vaccination

This case study focuses on the controversy surrounding the decision by Texas Governor Rick Perry to mandate the compulsory vaccination of girls in ...


Shannon and Jake

This case was developed to teach first-year medical students the basics of medical ethics. It describes a situation in which a family physician is ...


Shark Attack!

This case is based on the real-life incident of a boy whose arm was bitten off by a bull shark while swimming off the coast of Florida in the summe ...


Sick on a South American Sugarcane Plantation

This case study familiarizes readers with a disease that affects millions of people in Central and South America while illustrating a relatively un ...


Sickle Cell Anemia

In this case study on sickle cell anemia, students are introduced to some of the key researchers responsible for determining the molecular basis of ...


Skinny Genes?

This case study introduces Megi, an active teenager who has recovered from anorexia nervosa.  The method of progressive disclosure is used to ...


Sometimes It Is All in the Genes

Nancy, five months pregnant, agrees to a routine genetic test that indicates she carries the mutation for the fatal disease, cystic fibrosis. She c ...


Sometimes Less is Better

“Ed Cramer” is a 47-year-old mechanical engineer who is being treated for venous thromboembolism. He was 45 when he first developed a b ...


Spirituality and Health Care

In this medical ethics case, a fourth-year medical student making hospital rounds with an attending physician and several residents is asked by a f ...


Split My Brain

This case study involves a couple deciding whether or not their son should undergo brain surgery to treat a severe seizure disorder. In examining t ...


Statins Stat!

This case study describes a visit by "Naomi" to her physician, who upon seeing Naomi's bloodwork decides to prescribe her a cholesterol-lowering ag ...


Stubborn Grandma Mimi

Twenty-year-old “Drew” observes his grandmother “Mimi” decline as she stubbornly refuses treatment for her chronic kidney d ...


Stuck on Repeat

This interrupted case study is based on the real symptoms and laboratory results of a 65-year-old female stroke victim who is obese and on medicati ...


Super Bug

Sam, a pre-med college student, routinely gets dialysis and develops a urinary tract infection. The infection is from a bacterium that the news med ...


Take a Deep Breath

This interrupted case study tells the story of “Callie,” a 26-year-old baker from San Francisco who runs a successful new cupcake busin ...


The 1st New Disease of the 21st Century

This case study uses a PowerPoint (~1MB) combined with role-playing to present the epidemiology and pathophysiology of Severe Acute Respiratory Syn ...


The Case of Baby Joe

This interrupted case study follows the declining health of an infant who suffers from recurrent infections and finally is diagnosed with severe co ...


The Case of the Crying Baby

The parents of a six-week-old baby girl know there is something seriously wrong with their child, but it takes a number of frustrating visits to th ...


The Case of the Jamaican Fisherman

Designed for a first- or second-semester Anatomy & Physiology course, this directed case study involves a 48-year-old Jamaican fisherman who su ...


The Case of the Newborn Nightmare

Three newborns left in the care of "Dr. Mark Maddison" have developed a mysterious rash. Under increasing pressure from hospital administrators and ...


The Challenge of Epilepsy

This case study was originally developed for undergraduate science students as part of an extracurricular competition, but it could also be deliver ...


The Ebola Wars: Advanced Edition

This case study was written for upper level undergraduate and graduate students to review foundational aspects of virology and to examine Ebola vir ...


The Ebola Wars: General Edition

This case study introduces students to viruses and is suitable for a general biology course. Terry is a college student who travels to a West Afric ...


The Ebola Wars: Mission Immune Evasion

Through a unique anthropomorphic view and the integration of game-based learning, this case study explores how the Ebola virus can evade the immune ...


The Evolving Genetics of Disease Resistance

This interrupted case study for the flipped classroom applies evolutionary genetics research to human health. Students learn about a naturally occu ...


The Game Changer

This interrupted case study traces the football career of Anthony "Tony Tonka Truck" Williams, and the types of brain  trauma that he suffers ...


The Haemophilus Vaccine

This case study focuses on a young mother whose child attends a day care center where there has been an outbreak of bacterial meningitis. The case ...


The Medicinal Use of Marijuana

Whether marijuana should be legalized for medicinal purposes has been contested for decades. The claims, counter-claims, issues, and judgments in t ...


The Mystery of the Blue Death

This historical case study describes the story of John Snow’s discovery of water-borne transmission of cholera in 19th-century London. Design ...


The Path of a Pathogen

Scientists and healthcare professionals initially exhibited little concern over the Zika virus even after evidence of human infection was first ide ...


The Plan: Ethics and Physician Assisted Suicide

This case study on physician-assisted suicide is used in a medical ethics course. The case itself is a short article published in 1991 in the N ...


The Power of a Test

In this directed case study, students follow the story of “Marcus,” a recent college graduate who is working as a technician in a clini ...


Thyroid Troubles

In this interrupted case study, students shadow an endocrinologist as she tries to determine what is wrong with Angela Barber. Angela is a middle-a ...


To Tell the Truth

This case was developed to teach first-year medical students about medical ethics as they apply to patient communication. Students receive an intro ...


To Vaccinate, or Not to Vaccinate

The case was prompted by a newspaper story about a couple who refused on religious grounds to have their son vaccinated even though vaccination is ...


Too Many B Cells

Taylor's doctor notices she has swollen lymph nodes and an elevated white blood cell count on her routine annual exam and asks her to return for a ...


Tragic Choices: Autism, Measles, and the MMR Vaccine

This case explores the purported connection between vaccines in general, and the MMR vaccine specifically, and autism. Students examine results fro ...


Treating Ed

Ed is dying. How should his wishes for medical treatment be carried out? As the case unfolds, students explore the rights and responsibilities of d ...


Under the Knife and Completely Aware

This case study is based on a newspaper article about the suicide of Sherman Sizemore shortly after he underwent an exploratory laparotomy (abdomin ...


Up All Night

In this clicker case, students are introduced to George, an undergraduate student who has been experiencing some odd symptoms. His roommate convinc ...


Uretero What?

This case study follows a woman faced with a series of difficult medical decisions. Students apply systems-level physiology as they explore a pregn ...


Wake-Up Call

The main character of this case is Denise, who we first meet in the early morning hours as she wakes up in a cold sweat, gasping for breath. But it ...


We Are Not Alone

This interrupted case study for the flipped classroom introduces the human microbiome from the perspective of one of its occupants, Heidi Helicobac ...


Wearing on Her Nerves

This case study is designed to integrate important aspects of the nervous and muscular system portions of an anatomy and physiology course. Student ...


What's Wrong with Our Son?

In this interrupted case study, students examine the fundamental connections between genotype, 3-D protein structure and phenotype by exploring pos ...


When a Gene Turned Off Is a Matter of Life or Death

When Jordan is diagnosed with brain cancer (glioblastoma multiforme), his college plans are unexpectedly put on hold. This scenario is presented in ...


When Drug Sales and Science Collide

When "Jeff," a fictionalized drug representative, is placed on the Vioxx® account in 2001, he finds himself pulled between sales and science as ...


When Good Antibodies Go Bad

This interrupted case study was designed for an upper level course in immunology where the topic of autoimmunity is discussed in detail.  The ...


When Jenn Lost Her Nerve

In many physiology classes the frog neuromuscular junction (NMJ) is presented as the classic example of a chemical synapse, but many synapses show ...


When the Flu Is Not the Flu

This case study explores the progression of COVID-19 from initial flu-like symptoms to acute respiratory distress syndrome (ARDS) due to infection ...


When Work Makes You Sick

This case study was inspired by a real-life scenario, and follows the story of Roberto, a migrant farmworker whose health is impacted by the usage ...


Where’s the Evidence?

This analysis case study uses a jigsaw activity in which students learn about characteristics of the novel coronavirus causing COVID-19, SARS-CoV-2 ...


Which Came First, the Mutation or the Antibiotic?

This case study presents the story of Phil, an undergraduate majoring in biology, whose Russian cousin Dimitri has contracted tuberculosis (TB) fro ...


Who Killed Yew?

The purpose of this case is to teach introductory college biology students the basic process of mitosis, focusing on the fundamental cellular proce ...


Whose Job Is It, Really?

Medication reconciliation (MR) is the process of identifying the most accurate list of all medications a patient is taking, including the name, dos ...


Why Am I Always So Tired?

This case study consists of a role-play activity designed to simulate interactions between a patient and a health care provider. The patient, playe ...


Why is Patrick Paralyzed?

This “clicker case” introduces students to a rare genetic disease in which an enzyme is deficient in a critical metabolic pathway&mdash ...


Why Was the 1918 Influenza So Deadly?

In this intimate debate, students examine the causes of the devastation wrought by the 1918 Spanish Influenza pandemic. Students consider whether t ...


Wiggles Isn’t Wiggling: Apoptosis Edition

This case study tells the story of a family pet that is diagnosed with cancer.  Claire learns that her dog Wiggles has lymphoma, and that hist ...


Wiggles Isn’t Wiggling: Gene Expression Edition

This case study tells the story of a family pet that is diagnosed with cancer.  Claire learns that her dog Wiggles has lymphoma, and that hist ...


Woe Is Me

This case study tells the story of a 30-year-old man with intractable peptic ulcer disease. The persistence of the ailment, despite medical treatme ...


Woe to That Child

Alvin’s parents are worried about him. He has had a cough for almost a week, and he’s wheezing a lot more than they think is normal for ...


Yvette's Brave Battle

This case is based on the true story of a woman with choriocarcinoma, a rare type of rapidly dividing and metastatic cancer derived from cells of t ...


Zombie Attack!

Students assume the roles of CDC researchers who must determine how to most effectively stop an impending Zombie apocalypse. The story line leads s ...